Name: "T1E (Pan-ErbB Receptor) h(CD28-CD3_) Ligand-based CAR, pCDCAR1"
Availability: InStock

"T1E (Pan-ErbB Receptor) h(CD28-CD3_) Ligand-based CAR, pCDCAR1" | Creative Biolabs

Several studies have revealed aberrant expression or function of some ErbB receptors, mainly ErbB-2 dimers with ErbB-1 or ErbB-3, as a determinant of the pathogenesis of many malignancies, such as mesothelioma, epithelial ovarian carcinoma (EOC), or head and neck carcinoma [head and neck squamous cell (HNSCC)]. pan-ErbB CAR-T cell, a second-generation CAR-T therapy that includes T1E as a binding moiety for treating many epithelial malignancies.
Creative Biolabs provides a second-generation CAR vector which is designed using IL-11 peptide/protein as the extracellular domain. The vector is constructed for the engineering of T cells to target Human IL-19R_.