Name: "EPHB4 (EPHRIN B2 Receptor) h(CD28-CD3_) Ligand-based CAR, pCDCAR1"
Availability: InStock

"EPHB4 (EPHRIN B2 Receptor) h(CD28-CD3_) Ligand-based CAR, pCDCAR1" | Creative Biolabs

Ephrin type-B receptor 4 (EPHB4), a member of the family of receptor tyrosine kinases (RTKs), is ubiquitously expressed in distinct types of malignancies as rhabdomyosarcoma (RMS). In RMS and other malignancies, EPHRIN B2 interaction with EPHB4 may induce apoptosis and lack of proliferation (54). Based on the fact that EPHRIN B2 is a unique ephrin ligand that interacts with EPHB4, a second-generation CAR-T cell with an extracellular portion of EPHRIN B2 can be considered for RMS treatment.
Creative Biolabs provides a second-generation CAR vector which is designed using IL-11 peptide/protein as the extracellular domain. The vector is constructed for the engineering of T cells to target Human IL-13R_.