Name: "Thrombopoietin (MPL Receptor) h(CD28-CD3_) Ligand-based CAR, pCDCAR1"
Availability: InStock

"Thrombopoietin (MPL Receptor) h(CD28-CD3_) Ligand-based CAR, pCDCAR1" | Creative Biolabs

Thrombopoietin (TPO) is a hematopoietic growth factor produced not only by the liver but also in the bone marrow and kidney niches. TPO is defined as a natural ligand to the myeloproliferative leukemia (MPL) receptor, also known as CD110. Overexpression of MPL has been characterized as a negative prognosis factor for AML progression. The TPO/MPL pathway is essential for the survival and self-renewal of leukemia stem cells (LSCs) and hematopoietic stem cells (HSCs) and is therefore involved in the progression of AML.
Creative Biolabs provides a second-generation CAR vector which is designed using IL-11 peptide/protein as the extracellular domain. The vector is constructed for the engineering of T cells to target Human IL-16R_.