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Santa Cruz Biotechnology

c-Myc (9E10) PE | Santa Cruz Biotechnology

mouse monoclonal IgG1; Myc Antibody (9E10) is an IgG1 κ mouse monoclonal Myc antibody (also designated c-Myc antibody) that detects the Myc protein of mouse, rat, human, monkey, feline and canine origin by WB, IP, IF, IHC(P), FCM and ELISA. c-Myc Antibody (9E10) is available as both the non-conjugated anti-c-Myc antibody form, as well as multiple conjugated forms of anti-c-Myc antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. c-Myc-, N-Myc- and L-Myc-encoded proteins function in cell proliferation, differentiation and neoplastic disease. Amplification of the c-Myc gene has been found in several types of human tumors including lung, breast and colon carcinomas. Therefore, the c-Myc Antibody (9E10) is an important reagent in cancer research. The presence of three sequence motifs in the c-Myc COOH terminus of the Myc protein, including the leucine zipper, the helix-loop-helix and a basic region, provided initial evidence for a sequence-specific binding function. A basic region helix-loop-helix leucine zipper motif (bHLH-Zip) protein, designated Max, specifically associates with c-Myc, N-Myc and L-Myc proteins. The Myc-Max complex binds to DNA in a sequence-specific manner under conditions where neither Max nor Myc exhibits appreciable binding. Max can also form heterodimers with at least two additional bHLH-Zip proteins, Mad 1 and Mxi1, and Mad 1-Max dimers have been shown to repress transcription through interaction with mSin3

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ABOUT THE COMPANY

Santa Cruz Biotechnology is a world leader in the development of products for the biomedical research market. Over the past 30+ years, the Company has focused on the ongoing development of research antibodies, siRNA and CRISPR Gene editing tools, biochemicals, labware and more recently has expanded into animal health care products. Santa Cruz Biotechnology has the highest commitment to quality and customer service.