mouse monoclonal IgG2a; osteocalcin Antibody (C-8) is an IgG2a κ mouse monoclonal osteocalcin antibody that detects osteocalcin of human origin by WB, IP, IF and ELISA. osteocalcin Antibody (C-8) is available as the non-conjugated anti-osteocalcin antibody form, as well as multiple conjugated forms of anti-osteocalcin antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Bone g-carboxyglutamic acid (Gla) protein, known as BGLAP, BGP or osteocalcin, is an abundant, non-collagenous protein component of bone that is produced by osteoblasts. In mice, osteocalcin is composed of a cluster of 3 genes known as OG1, OG2 and ORG, all of which can be found within a 23Kb span of genomic DNA. Human osteocalcin is a highly conserved, 46-50 amino acid, single chain protein that contains three vitamin K-dependent g-carboxyglutamic acid residues. Osteocalcin appears transiently in embryonic bone at the time of mineral deposition, where it binds to hydroxyapatite in a calcium-dependent manner. In addition, osteocalcin is one of the most abundant, non-collagenous proteins found in mineralized adult bone. Genetic variation at the osteocalcin locus on chromosome 1q impacts postmenopause bone mineral density (BMD) levels and may predispose some women to osteoporosis.