Cells carry out specialized functions throughout the body and each cell type functions distinctly from other cell types. Some cellular functions include transporting nutrients throughout the body and producing energy. One specialized cell is muscle cells which function to create a force that moves parts of the body. Another example are bone cells, whose functions include protecting internal organs from damage and storing minerals such as calcium.
The microenvironment of many solid tumors impedes many immunotherapeutic treatments by inhibiting the effector functions of many classes of anti-tumor immune cells, including effector T cell...
The ultimate promise of tumor immunotherapy is dependent on the generation of effective immunity against cancer, including CD4 and CD8 T cell responses. However, activating T cells in cancer...
We recently determined that concurrent inhibition of autophagy, using the lysosomal inhibitor chloroquine (CQ), and of ERK, using a small molecule ERK inhibitor (ERKi), synergistically suppr...
Date: September 29, 2022 Time: 9:00am (PST), 12:00pm (EST), 6:00pm (CEST) The increased complexities of high throughput workflows within the lab can create demands on researchers. As your la...
Date: September 27, 2022 Time: 8:00am (PDT), 11:00pm (EDT), 5:00pm (CEST) Temperature sensitive (TS) alleles are mutations in essential genes that allow for growth at permissive temperatures...
α-synuclein (-syn) is a small presynaptic protein linked to the pathogenesis of Parkinson’s disease (PD) and related disorders, collectively called synucleinopathies. Phosphoryl...
Heterotetrameric adaptor protein (AP) complexes play key roles in protein sorting and transport vesicle formation in the endomembrane system of eukaryotic cells. One of these complexes, AP-4...
Microphysiological systems (MPS) have proven to be a powerful tool for recreating human tissue- and organ-like functions. However, establishing complex human in vitro ADME models involving c...
Within the kidney, the glomerulus is the structure in charge of the renal ultrafiltration. Loss of glomerular function leads to renal damage and could end with irreversible damage. The major...
One of the primary limitations in drug discovery and toxicology research is the lack of good model systems between the single cell level and animal or human systems. This is especially true...
Human Allogeneic Liver-derived Progenitor Cells (HALPC; HepaStemTM) are an advanced therapy medicinal product composed of medicinal signaling cells derived and expanded from healthy human li...
The use of primary human hepatocytes in basic research or other clinical applications (e.g., liver assist devices, ex vivo gene therapy, and hepatocyte transplantation) is limited by a short...
Intracellular signaling processes are frequently based on direct interactions between proteins and organelles. A fundamental strategy to elucidate the physiological significance of such inte...
Alphaviruses are enveloped RNA viruses that cause disease in humans ranging from acute febrile illness with rash and arthritis to lethal encephalitis. Like many other mosquito-borne viruses,...
Recent outbreaks of Ebola virus (EBOV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have exposed our limited therapeutic options for such diseases and our poor understand...
Learning Objectives 1. Understand the life cycle of the malaria causing parasite, Plasmodium 2. Understand new approaches to identifying host regulators of infection 3. Describe advantages a...
As obligate intracellular pathogens, viruses require host-derived nucleotides, amino acids, and lipids, among others, and the bioavailability of these metabolites can restrict or promote vir...
Altered enteric microorganisms in concert with host genetics shape inflammatory bowel disease (IBD) phenotypes. However, insight is limited to bacteria and fungi. We found that eukaryotic vi...
Many clinically approved drugs that are prescribed to modulate human physiology are also potent antimicrobials at physiological concentrations. Recent systematic studies indicate that bacter...
Date: August 24, 2022 Time: 7:00am (PDT), 10:00pm (EDT), 4:00pm (CEST) Light field microscopy was first introduced in 2006, and allows users to capture the 4D light field within the microsco...
Date: August 18, 2022 Time: 3pm AEST | 1pm SGT | 2pm JP/KR Kirsten rat sarcoma viral oncogene homologue (KRAS) is the most frequently mutated oncogene, present in approximately 25% of tumors...
Date: August 16, 2022 Time: 9:00am (PST), 12:00pm (EST), 6:00pm (CEST) Combining our rich experience in molecular biology and cell system engineering, GenScript has established the TurboCHO&...
Date: December 09, 2022 Time: 11:00am (PST), 2:00pm (EST), 8:00pm (CEST) Flow cytometry is a trusted method to monitor T cell phenotype, plasticity, and functionality in basic research as we...
The microenvironment of many solid tumors impedes many immunotherapeutic treatments by inhibiting the effector functions of many classes of anti-tumor immune cells, including effector T cell...
The ultimate promise of tumor immunotherapy is dependent on the generation of effective immunity against cancer, including CD4 and CD8 T cell responses. However, activating T cells in cancer...
We recently determined that concurrent inhibition of autophagy, using the lysosomal inhibitor chloroquine (CQ), and of ERK, using a small molecule ERK inhibitor (ERKi), synergistically suppr...
Date: September 29, 2022 Time: 9:00am (PST), 12:00pm (EST), 6:00pm (CEST) The increased complexities of high throughput workflows within the lab can create demands on researchers. As your la...
Date: September 27, 2022 Time: 8:00am (PDT), 11:00pm (EDT), 5:00pm (CEST) Temperature sensitive (TS) alleles are mutations in essential genes that allow for growth at permissive temperatures...
α-synuclein (-syn) is a small presynaptic protein linked to the pathogenesis of Parkinson’s disease (PD) and related disorders, collectively called synucleinopathies. Phosphoryl...
Heterotetrameric adaptor protein (AP) complexes play key roles in protein sorting and transport vesicle formation in the endomembrane system of eukaryotic cells. One of these complexes, AP-4...
Microphysiological systems (MPS) have proven to be a powerful tool for recreating human tissue- and organ-like functions. However, establishing complex human in vitro ADME models involving c...
Within the kidney, the glomerulus is the structure in charge of the renal ultrafiltration. Loss of glomerular function leads to renal damage and could end with irreversible damage. The major...
One of the primary limitations in drug discovery and toxicology research is the lack of good model systems between the single cell level and animal or human systems. This is especially true...
Human Allogeneic Liver-derived Progenitor Cells (HALPC; HepaStemTM) are an advanced therapy medicinal product composed of medicinal signaling cells derived and expanded from healthy human li...
The use of primary human hepatocytes in basic research or other clinical applications (e.g., liver assist devices, ex vivo gene therapy, and hepatocyte transplantation) is limited by a short...
Intracellular signaling processes are frequently based on direct interactions between proteins and organelles. A fundamental strategy to elucidate the physiological significance of such inte...
Alphaviruses are enveloped RNA viruses that cause disease in humans ranging from acute febrile illness with rash and arthritis to lethal encephalitis. Like many other mosquito-borne viruses,...
Recent outbreaks of Ebola virus (EBOV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have exposed our limited therapeutic options for such diseases and our poor understand...
Learning Objectives 1. Understand the life cycle of the malaria causing parasite, Plasmodium 2. Understand new approaches to identifying host regulators of infection 3. Describe advantages a...
As obligate intracellular pathogens, viruses require host-derived nucleotides, amino acids, and lipids, among others, and the bioavailability of these metabolites can restrict or promote vir...
Altered enteric microorganisms in concert with host genetics shape inflammatory bowel disease (IBD) phenotypes. However, insight is limited to bacteria and fungi. We found that eukaryotic vi...
Many clinically approved drugs that are prescribed to modulate human physiology are also potent antimicrobials at physiological concentrations. Recent systematic studies indicate that bacter...
Date: August 24, 2022 Time: 7:00am (PDT), 10:00pm (EDT), 4:00pm (CEST) Light field microscopy was first introduced in 2006, and allows users to capture the 4D light field within the microsco...
Date: August 18, 2022 Time: 3pm AEST | 1pm SGT | 2pm JP/KR Kirsten rat sarcoma viral oncogene homologue (KRAS) is the most frequently mutated oncogene, present in approximately 25% of tumors...
Date: August 16, 2022 Time: 9:00am (PST), 12:00pm (EST), 6:00pm (CEST) Combining our rich experience in molecular biology and cell system engineering, GenScript has established the TurboCHO&...
Date: December 09, 2022 Time: 11:00am (PST), 2:00pm (EST), 8:00pm (CEST) Flow cytometry is a trusted method to monitor T cell phenotype, plasticity, and functionality in basic research as we...
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