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Tumor Inflammation Signature
The Tumor Inflammation Signature (TIS) is a measurement of the adaptive immune response in a tumor. The TIS incorporates expression of 18 genes involved in important adaptive immune functions including antigen presentation, chemokine expression, and cytotoxic activity. TIS is correlated with response to anti-PD-1 immunotherapy.
MAY 20, 2020 | 11:15 AM
Background: CDK4/6 inhibitors increase tumor immunogenicity in preclinical models of breast cancer and several trials combining CDK4/6 inhibitors and anti-PD1/PDL1 therapies are underway. Ho...
MAY 19, 2020 | 1:45 PM
Targeted therapies for cancer are increasingly being developed as an alternative for, and in addition to, immunotherapy. Altered tumor signaling can be exploited to single-out cancer cells f...
NOV 09, 2017 | 9:00 AM
Transcriptional profiling of the tumor microenvironment can lead to insights about the interaction between the tumor and immune system. This facilitates investigation of immune evasion mechan...
NOV 09, 2017 | 9:00 AM
Transcriptional profiling of the tumor microenvironment can lead to insights about the interaction between the tumor and immune system. This facilitates investigation of immune evasion mechan...