SEP 15, 2018 10:00 AM PDT

Undescended testicles could lead to testicular cancer and infertility in adult males

Undescended testes. Credit: The Royal Children's Hospital Melbourne

An undescended testis (cryptorchidism) is a condition in which one or both of the testes have not descended into the right position in the scrotum at birth and either stay at the abdomen or descend partly into the scrotum.

Usually, the undescended testis moves into its right position into the scrotum by itself within a few months after birth, but if that did not happen children must undergo surgery ‘orchidopexy’ to relocate the testicle into the scrotum.

Medical guidelines are recommending this surgery before 18 months of age to decrease the risk of any complications to undescended testis as testicular cancer and adult male infertility. Researchers at the University of Sydney published a new study that confirms the need to comply with these guidelines.

The study that was published in The Lancet Child & Adolescent Health is considered the first population-based cohort study to evaluate testicular cancer and infertility risk after the correction surgery. It is a study of 350,835 boys born in Western Australia between 1970 and 1999 and followed them up until 2016 via data linked to different resources as hospital admissions.

They discovered that the risk for adult testicular cancer increased 2.4 times for boys suffering from undescended testes compared to healthy boys. Also, the risk of testicular cancer was higher by 6% with each 6-month increase in age at the time of surgery.

As for the risk of infertility, it increased by 20% for the affected boys compared with the healthy ones, and they had twice the chance of using assisted reproductive technology for infertility as adults.

“In addition to an increased risk of testicular cancer, we found that boys with undescended testes had decreased paternity and increased use of assisted reproductive technologies for infertility in later life,” said the University of Sydney’s Professor Natasha Nassar, the study’s senior author.

“Before this study, there was no evidence-based information on the impact of early surgery on the future risk of testicular cancer and infertility in adult males,” said study leader, Dr. Francisco Schneuer of the University of Sydney.

As Testicular cancer is the second most common cancer in young males and although it is rare, its occurrence has increased by 50% in the last 30 years, and male infertility affects 5-10% of men worldwide. Therefore, parents should be more aware of early diagnosing undescended testes and comply with the guidelines to undergo surgery as early as possible if it is required to lower the risk of any complications.

Watch the video below to learn more about undescended testicles and the corrective surgery.

Source: ScienceDaily via The University of Sydney, ScienceDirect

About the Author
  • A master student in Biochemistry and Molecular biology with experience in Education and Research. I am passionate about scientific research and passing my knowledge to others to help them learn about the latest in science by teaching, writing and volunteering in scientific events.
You May Also Like
JUN 06, 2018
Cell & Molecular Biology
JUN 06, 2018
New Role for Protein Complex Provides Insight Into Cancer Development
Researchers found that RSC plays an important role in chromosome distribution....
JUN 20, 2018
Cancer
JUN 20, 2018
Peruvian Plant's Unique Anti-Tumor Biological Mechanism Discovered
Plagiochiline A is a molecule that exhibits antiproliferative properties and is cytotoxic. New research outlines the unique biological mechanism valued as possible cancer therapy target....
AUG 07, 2018
Cancer
AUG 07, 2018
Is There a Best Time of Day to Administer Chemo?
A common hematologic cancer chemotherapy agent is looked at for its efficacy on solid tumors and specifically evaluates if delivery time during the day affects is anti-tumor activity....
OCT 03, 2018
Cell & Molecular Biology
OCT 03, 2018
Single Cell Modified in CAR T Therapy Causes Deadly Relapse
One cell meant a very different outcome for a patient that was the recipient of a cutting-edge cancer therapy....
OCT 14, 2018
Immunology
OCT 14, 2018
The Stem of Cancer
Scientists reveal a pathway involved in cancer cell ability to act as stem cells...
OCT 17, 2018
Cell & Molecular Biology
OCT 17, 2018
Saving Patients From Unnecessary Chemotherapy with a Blood Test
Often, cancer patients get chemotherapy after surgery to ensure that their cancer will not come back; for many it's not needed....
Loading Comments...