JUN 13, 2019 11:44 AM PDT

Proton Therapy May Reduce Second Cancer Risk More Than Other Radiation Types

WRITTEN BY: Julia Travers

A new study finds that proton beam radiation therapy (PBRT) might lead to a reduction in the risk for a second cancer, when compared to other types of contemporary radiation therapy. The researchers analyzed National Cancer Database (NCDB) data on adult and pediatric patients with cancer. It used the data to determine the second-cancer risk associated with three types of radiation therapy (RT):  PBRT, intensity-modulated radiation therapy (IMRT) and three-dimensional conformal radiation therapy (3DCRT). The therapies included were administered between 2004 and 2016 to patients of diverse ages, and those with metastatic disease were not included.

PBRT, credit: public domain

PBRT Study Design and Findings

Head and/or neck, breast, gastrointestinal, gynecologic, non–small cell lung, prostate, bone/soft tissue, lymphoma and brain/central nervous system tumors were included. The total number of patients whose data were analyzed was 450,373. The percentage of people who also received chemotherapy was higher in the 3DCRT group, at 48 percent, and lower in the IMRT and PBRT groups, which were at 38 and 17 percent, respectively. PBRT was used most with prostate tumors. Head and neck cancers were treated primarily with IMRT, and 3DCRT was utilized most often for breast cancers.

The crude absolute incidence rate of subsequent cancer diagnosis per 100 patient-years was 1.60 in the 3DCRT cohort, 1.55 in the IMRT cohort, and 0.44 in the PBRT cohort.

PBRT Study Conclusions and Limitations

“Patients most likely to benefit from PBRT may be [children] and young adults due to the potential for a long life expectancy and increased susceptibility to treatment-related malignancies,” Michael Xiang, M.D., Ph.D., of Stanford University, said.

Some of the study’s constraints were tied to the NCDB, which does not allow researchers to discern the location of a second cancer relative to an RT field. The database also does not account for risk factors like obesity or smoking, among other limitations.

To learn the basics of how proton therapy treats cancer, check out the video below.

Source: ASCO News

 

About the Author
  • Julia Travers is a writer, artist and teacher. She frequently covers science, tech, conservation and the arts. She enjoys solutions journalism. Find more of her work at jtravers.journoportfolio.com.
You May Also Like
JUN 09, 2021
Clinical & Molecular DX
Faster, Cheaper Diagnosis of Rare Cancer in Fat Cells
JUN 09, 2021
Faster, Cheaper Diagnosis of Rare Cancer in Fat Cells
Scientists have created a gene panel test to quickly and more precisely diagnose common forms of liposarcoma. This break ...
JUN 10, 2021
Cell & Molecular Biology
Does Lithium Prevent Colon Cancer?
JUN 10, 2021
Does Lithium Prevent Colon Cancer?
Researchers found that a drug used in the treatment of mental illness can promote the fitness of healthy gut stem cells, ...
JUN 14, 2021
Health & Medicine
Another Benefit of Aspirin: Decreased Colorectal Cancer Risk When Started Early
JUN 14, 2021
Another Benefit of Aspirin: Decreased Colorectal Cancer Risk When Started Early
Valued for stroke and heart attack prevention, aspirin is also recommended for colorectal cancer prevention. A Harv ...
JUN 05, 2021
Cancer
How is the new hospital price transparency rule going?
JUN 05, 2021
How is the new hospital price transparency rule going?
New findings from an analysis of hospital price transparency have been published recently in JAMA. The analysis was ...
JUN 11, 2021
Cancer
Man beats brain cancer with ketogenic diet
JUN 11, 2021
Man beats brain cancer with ketogenic diet
Glioblastoma brain cancer continues to be one of the most fatal cancers, responsible for approximately 15,000 death ever ...
OCT 11, 2021
Cancer
Different Cancer Types Metastasize to Specific Regions of the Brain
OCT 11, 2021
Different Cancer Types Metastasize to Specific Regions of the Brain
Metastatic cancer occurs when cancer spreads from its original site of origin to a distant location in the body. Wh ...
Loading Comments...