AUG 17, 2019 8:44 AM PDT

New method to stop metastasis in lymph nodes

Research reported recently in ACS Nano explains a new method of targeting metastases in lymph nodes as a means of preventing the spread of cancers. The approach could provide novel treatment methods for patients vulnerable to metastasis, the process during which cancer cells separate from the primary tumor to form tumors at other sites. Metastasis is leading cause of cancer deaths.

This strategy targets lymph nodes because metastatic cancer usually spreads first to these glands through small vessels called lymphatics, which carry immune cells and fluid. While most conventional treatment options utilize biopsies of the lymph nodes to see if metastasis has occurred, taking a biopsy is an invasive procedure that can cause pain and infection. Instead of biopsies, the method developed by researchers Hong-Jun Li, Jin-Zhi Du and colleagues uses a nanoparticle delivery tool, called iCluster.

iCluster is already used as a nanoparticle delivery tool to bring chemotherapies directly to tumors, but by injecting iCluster combined with a red dye into mice with tumors, the researchers figured out that iCluster is also capable of entering a tumor and passing through the lymphatics. Using fluorescent imaging, the scientists saw that this mechanism provides a channel to target the lymph nodes directly and potentially treat metastases.

The study concluded that 40% of the treated mice treated with iCluster were still alive 110 days following the removal of the tumor; in comparison, those mice that did not receive treatment from iCluster before the removal of tumors all died from metastases within 51 days of surgery. Additionally, while the iCluster-treated mice lived longer, they also were seen to have far fewer tumors than untreated mice.

The authors explain their findings, stating, “Here, we uncovered that improved perfusion in a primary tumor facilitates nanoparticle translocation to lymph nodes for inhibiting tumor metastasis. On the basis of our finding that an iCluster platform…markedly improved particle perfusion in the interstitium of the primary tumor, we further revealed in the current study that such tumor-specific size transition promoted particle intravasation into tumor lymphatics and migration into lymph nodes.”

Sources: Science Daily, ACS Nano

About the Author
BA Environmental Studies
Kathryn is a curious world-traveller interested in the intersection between nature, culture, history, and people. She has worked for environmental education non-profits and is a Spanish/English interpreter.
You May Also Like
AUG 29, 2022
Cancer
Could Robotic Surgery Provide Better Care for Patients with Kidney Cancer?
AUG 29, 2022
Could Robotic Surgery Provide Better Care for Patients with Kidney Cancer?
Renal cell carcinoma (RCC) is the most common type of kidney cancer, accounting for about 90% of kidney cancer incidence ...
OCT 07, 2022
Drug Discovery & Development
A wearable sensor that can monitor tumor size changes in real-time
OCT 07, 2022
A wearable sensor that can monitor tumor size changes in real-time
As cancer drugs are developed, one important process the drug goes through is testing in experimental animals. The use o ...
NOV 17, 2022
Cancer
Anti-Aging Supplement Linked to Aggressive Breast Cancer
NOV 17, 2022
Anti-Aging Supplement Linked to Aggressive Breast Cancer
Vitamin B3, also known as niacin, is a generic name for a group of biochemical compounds, including nicotinamide ribosid ...
NOV 17, 2022
Drug Discovery & Development
Implantable Pump Delivers Chemotherapy Directly to the Brain
NOV 17, 2022
Implantable Pump Delivers Chemotherapy Directly to the Brain
An implantable pump can bypass the blood-brain barrier and deliver chemotherapy to specific brain areas. The correspondi ...
NOV 24, 2022
Cancer
Pass the Cranberries- They Just Might Help Prevent Cancer
NOV 24, 2022
Pass the Cranberries- They Just Might Help Prevent Cancer
Today across the United States, families gather to celebrate Thanksgiving, a day to give thanks for the previous year&rs ...
NOV 22, 2022
Clinical & Molecular DX
Women With Benign Breast Diseases, Including Cysts and Fibroadenomas, Face Higher Risk of Breast Cancer
NOV 22, 2022
Women With Benign Breast Diseases, Including Cysts and Fibroadenomas, Face Higher Risk of Breast Cancer
Though they are very common, benign breast diseases may indicate an increased likelihood of developing breast cancer at ...
Loading Comments...