OCT 03, 2019 05:16 PM PDT

Scientists develop a single delivery immunotherapy threatment

Research published recently in Cell Stem Cell details the results from a new anticancer immunotherapy that uses invariant natural killer T (iNKT) cells. The findings highlight the potential of iNKT cells to fight against many different types of cancer cells by suppressing tumor growth.

Led by researchers at UCLA, the research focused on iNKT cells because of their immune system capabilities. As Senior author Lili Yang, Ph.D. explains, "They are very powerful cells, but they're naturally present in such small numbers in the human blood that they usually can't make a therapeutic difference." The researchers wanted to find out if increasing the natural level of iNKT cells in the body would help fight cancer cells.

In conducting the research, the team used different mouse models to test out a therapy that stimulates the production of iNKT cells by way of hematopoietic stem cells from bone marrow. The resulting cells they named "hematopoietic stem cell-engineered invariant natural killer T cells" (or, HSC-iNKT). The most imperative part of this breakthrough is that the HSC-iNKT cells continued to be produced throughout the mouse models’ lives, meaning that the therapy could be a single-delivery cell therapy capable of giving patients a lifelong supply of iNKT cells!

"What's really exciting is that we can give this treatment just once, and it increases the number of iNKT cells to levels that can fight cancer for the lifetime of the animal," comments Dr. Yang.

Researchers use iNKT cells to develop new anticancer immunotherapy. Photo: Pixabay

Not only was the process of producing iNKT cells from HSC-iNKT cells successful, but the animal models also showed significant suppression of both multiple myeloma and melanoma tumor growth, the two types of cancer that the researchers were testing.

Although this treatment was only tested on animal models and has yet to reach human clinical trials, the researchers hope that their findings could be a ray of light for cancer patients in the future.

Sources: Cell Stem Cell, Medical News Today

About the Author
  • Kathryn is a curious world-traveller interested in the intersection between nature, culture, history, and people. She has worked for environmental education non-profits and is a Spanish/English interpreter.
You May Also Like
NOV 18, 2019
Drug Discovery & Development
NOV 18, 2019
Chemotherapeutics react differently to radiation
Patients with various types of cancer are almost always treated with a combination of chemotherapy and radiotherapy. In chemotherapy, therapeutics consist ...
NOV 18, 2019
Cell & Molecular Biology
NOV 18, 2019
Stem Cell Derived Natural Killer T Cells as Novel and Long-term Cancer Treatment
Hematopoietic stem cells are used to create a population of Natural Killer T-cells that could sustain and renew within the immune system, and attack cancer cells....
NOV 18, 2019
Drug Discovery & Development
NOV 18, 2019
Compound in Daffodils Can Help Fight Cancer
Preventing the growth of tumors presents a challenge for scientists in finding a cure to cancer. Now however, researchers from the University Libre de Brux...
NOV 18, 2019
Genetics & Genomics
NOV 18, 2019
A Cancer-Promoting Mutation is Found in 'Junk' DNA
A huge amount of our genome does not code for protein, but it can impact physiology in other ways....
NOV 18, 2019
Cancer
NOV 18, 2019
C2 combination targets cancer cells more efficiently
Treating cancer is in part so difficult because to be effective, high doses of aggressive drugs must be administered to patients. These treatments often ha...
NOV 18, 2019
Cancer
NOV 18, 2019
An astronaut's training for cancer patients
The comparison is perhaps unexpected, but the findings show potential: astronauts experience similar physical stress in spaceflight as cancer patients rece...
Loading Comments...