OCT 07, 2019 2:51 PM PDT

Gut fungi linked to pancreatic cancer

In a recent paper published in Nature paper, researchers from the New York University (NYU) School of Medicine in NYC report that gut fungi may be linked to pancreatic cancer. The study was conducted in mice and humans with pancreatic cancer and provides hope for developments in future treatments for patients with pancreatic cancer.

"While past studies from our group have shown that bacteria travel from the gut to the pancreas," says co-senior study author Dr. George Miller, MD, "our new study is the first to confirm that fungi, too, make that trip and that related fungal population changes promote tumor inception and growth."

In conducting the study, Dr. Miller and his fellow researchers analyzed stool samples from mice with and without pancreatic ductal adenocarcinoma, or PDA, the most common type of pancreatic cancer. By putting fluorescent proteins onto the fungi, they were able to monitor the changes in the fungal populations over 30 weeks, as well as track their movement from the intestines to the pancreas.

From this analysis, they determined that in both mice and human tissues with pancreatic cancer, the population sizes and compositions of fungi was different than that of those without pancreatic cancer. The fungi that were observed to have the largest population size in cancerous pancreatic tissues were those in the species belonging to the genus Malassezia. They also observed a less significant increase in fungal species such as those in Parastagonospora, Saccharomyces, and Septoriella.

"We have long known that Malassezia fungi — generally found on the skin and scalp — are responsible for dandruff and some forms of eczema, but recent studies have also linked them to skin and colorectal cancer," says co-senior study author Deepak Saxena, Ph.D., a professor in the College of Dentistry at NYU. "Our new findings add to evidence that Malassezia is abundant in pancreatic tumors as well."

Pancreatic cancer is hard to detect, so many people receive diagnoses when the cancer has already advanced. Photo: Pixabay

The hope that stems from this discovery comes from the success that antifungal drug treatments had on combating pancreatic cancer. According to the study, treating the diseased mice with a strong antifungal drug called amphotericin B reduced tumor weight by 20–40%. In addition, explains Medical News Today, “The treatment also reduced ductal dysplasia, an early stage in the development of pancreatic cancer, by 20–30% and antifungal treatment also boosted the anticancer power of gemcitabine, a standard chemotherapy drug, by 15–25%.”

This could mean big news for future pancreatic cancer treatment. Pancreatic cancer one of the 10 most common cancers in both males and females in the United States, according to the CDC, and because it is difficult to detect, people are often diagnosed when it is already in an advanced stage. In the US alone, 45,750 are expected to die of the disease this year.

Sources: Nature, Medical News Today

About the Author
  • Kathryn is a curious world-traveller interested in the intersection between nature, culture, history, and people. She has worked for environmental education non-profits and is a Spanish/English interpreter.
You May Also Like
JUN 23, 2021
Cancer
Military universal health system boasts higher survival rates for colon cancer patients
JUN 23, 2021
Military universal health system boasts higher survival rates for colon cancer patients
New results published in the American Association for Cancer Research journal Cancer Epidemiology, Biomarkers & Prev ...
AUG 19, 2021
Immunology
Immune Enzyme Kills Viruses but Makes Tumors Stronger
AUG 19, 2021
Immune Enzyme Kills Viruses but Makes Tumors Stronger
Robert Louis Stevenson’s 1886 novel Strange Case of Dr. Jekyll and Mr. Hyde describes a man who is a kind, respect ...
AUG 25, 2021
Cell & Molecular Biology
Sino Biological's Listing on the Shenzhen Stock Exchange
AUG 25, 2021
Sino Biological's Listing on the Shenzhen Stock Exchange
China, August 16, 2021 - Sino Biological, Inc. (“Sino Biological” or the “Company”), a biot ...
AUG 29, 2021
Cancer
Blood Test over 90% Accurate in Detecting Lung Cancer
AUG 29, 2021
Blood Test over 90% Accurate in Detecting Lung Cancer
An AI-powered blood test was able to correctly detect the presence of lung cancer over 90% of the time in patient sample ...
SEP 20, 2021
Cancer
An Established Ovarian Cancer Antigen Presents a Promising Therapeutic Target
SEP 20, 2021
An Established Ovarian Cancer Antigen Presents a Promising Therapeutic Target
For the past several decades, cancer antigen 125 (CA 125), a protein located on the surface of ovarian cancer cells, has ...
SEP 21, 2021
Drug Discovery & Development
Lifesaving TheraSpheres - glass microbeads can target and destroy colorectal tumors
SEP 21, 2021
Lifesaving TheraSpheres - glass microbeads can target and destroy colorectal tumors
The innovative medical device manufacturer Boston Scientific recently showed success in treating patients with ...
Loading Comments...