NOV 01, 2019 9:42 PM PDT

C2 combination targets cancer cells more efficiently

Treating cancer is in part so difficult because to be effective, high doses of aggressive drugs must be administered to patients. These treatments often have negative side effects on healthy cells and can also lead to progressive resistance to treatment drugs. That’s why new research published in the journal Cancers showcasing a combination of four anti-cancer components that could be capable of attacking cancerous cells while leaving healthy cells alone is so exciting. The research comes from scientists at the University of Geneva (UNIGE), Switzerland who analyzed 10 substances in 200 different combinations to find the lucky one that they’re calling C2.

C2 consists of four products (tubacin, CI-994, erlotinib and dasatinib) and works by targeting the supernumerary centrosomes that are only found in tumor cells (watch the video above to learn more). By doing so, C2 can provoke cell deaths specific to only tumor cells. "During our in vitro tests, we found that C2 killed up to 20 times more cancer cells than other combinations, while sparing healthy cells," explains Patrick Meraldi, who is a professor in the Department of Cellular Physiology and Metabolism in UNIGE's Faculty of Medicine as well as at the university's Translational Research Centre in Onco-Haematology (CRTOH).

To figure this out, the researchers used a simultaneous validation technique that they developed. "We used a method we developed in our laboratory to test these different combinations simultaneously in vitro on a cancer cell and on a healthy cell. The aim was to directly compare the effects of the treatment on the two types of cells," elaborates Patrycja Nowak-Sliwinska, a professor in the Institute of Pharmaceutical Sciences of Western Switzerland and at UNIGE and CRTOH. "We were able to eliminate the formulas that didn't destroy the diseased cells together with those that also had an impact on the healthy cells.

Scientists hope C2 will serve more effectiively to target cancer cells while leaving healthy cells alone. Photo: Pixabay

This research holds great potential for the future of anti-cancer treatments, particularly when it comes to lowering doses. “The main objective is to reduce the doses of the drugs so we can avoid resistance," explains Nowak-Sliwinska. "That's why we're creating new formulas made up of several low-dose treatments that will help us achieve our goal without inducing any resistance."

The researchers plan to continue their investigations, moving from in vivo testing on mice to monitoring the effects of C2 on the entire body.

Sources: Cancers, Science Daily

About the Author
  • Kathryn is a curious world-traveller interested in the intersection between nature, culture, history, and people. She has worked for environmental education non-profits and is a Spanish/English interpreter.
You May Also Like
MAY 27, 2021
Cancer
Which ovarian cancer patients will be resistant to platinum chemotherapy?
MAY 27, 2021
Which ovarian cancer patients will be resistant to platinum chemotherapy?
Research published in the journal EMBO Molecular Medicine details a novel mechanism that can be used to predict which ep ...
JUN 10, 2021
Cell & Molecular Biology
Does Lithium Prevent Colon Cancer?
JUN 10, 2021
Does Lithium Prevent Colon Cancer?
Researchers found that a drug used in the treatment of mental illness can promote the fitness of healthy gut stem cells, ...
JUN 27, 2021
Cancer
Are e-cigarettes actually helpful for smoking cessation?
JUN 27, 2021
Are e-cigarettes actually helpful for smoking cessation?
New research published in The Lancet Public Health reports on a study that looked at interventions targeting e-cigarette ...
JUN 29, 2021
Cancer
Heart Failure Linked to Increased Cancer Risk
JUN 29, 2021
Heart Failure Linked to Increased Cancer Risk
A study by researchers in Germany suggests that patients with heart failure are more likely to develop cancer than those ...
AUG 19, 2021
Cancer
Japanese Berry Vine Could Treat Lung Cancer
AUG 19, 2021
Japanese Berry Vine Could Treat Lung Cancer
A berry-producing vine in Japan has shown promise in mouse models for treating lung cancer. The corresponding study was ...
AUG 24, 2021
Clinical & Molecular DX
A New Chapter in Metastatic Breast Cancer Biomarkers
AUG 24, 2021
A New Chapter in Metastatic Breast Cancer Biomarkers
For patients diagnosed with metastatic breast cancer, it’s often not the primary tumor that has fatal consequences ...
Loading Comments...