JUN 27, 2020 12:00 PM PDT

How radiomics can help detect lung cancer

A new study published in the journal Nature Scientific Reports offers an alternative form of lung cancer screening using radiomics. Current screening is conducted using low dose computed tomography (CT) while effective in certain scenarios, CT screening has its limitations. The new technique, described by researchers at the Moffitt Cancer Center, is better adept at identifying early-stage lung cancer patients who may be at high risk for poorer outcomes. 

"Our goal was to use radiomic features to develop a reproducible model that can predict survival outcomes among patients who are diagnosed during a lung cancer screening," said lead author Jaileene Pérez-Morales, Ph.D., who is a postdoctoral fellow at Moffitt. 

Radiomics is a method that extracts large amounts of features such as biomarkers from radiographic medical images using data-characterization algorithms. According to Eureka Alert, radiomics “has advantages over circulating and tissue-based biomarkers because radiomic features are calculated from standard-of-care imaging and reflect the entire tumor burden, not just a sample of the tumor.” Watch the video below to learn more about radiomics. 

In conducting the study, the researchers analyzed data of lung cancer tumors in order to compare low dose CT and standard chest x-ray screening methods. From their analysis of the size, shape, volume, and texture of the tumors, the scientists developed a model to identify and stratify patients based on risk level and radiomic features. This model can then predict which patients may require frequent follow-up therapy based on the identified radiomic features.

The researchers say that early detection by this method could help identify which patients require aggressive adjuvant therapy. "Identifying predictive biomarkers that detect aggressive cancers or those that may be slowly developing and non-emergent is a critical unmet need in the lung cancer screening setting," said Matthew Schabath, Ph.D., an associate member of the Cancer Epidemiology Department at Moffitt. "Additional research is needed to inform us on the potential translational implications of this model, but it could make a major impact on saving lives by identifying lung cancer patients with an aggressive disease while also sparring others from unnecessary therapy."

Photo: Pixabay

Sources: Nature Scientific Reports, Eureka Alert

About the Author
  • Kathryn is a curious world-traveller interested in the intersection between nature, culture, history, and people. She has worked for environmental education non-profits and is a Spanish/English interpreter.
You May Also Like
JUN 25, 2020
Cancer
Examining the Glioma Influenced Immune System
JUN 25, 2020
Examining the Glioma Influenced Immune System
The human body is a complicated network of systems and signals.  Many systems regulate themselves or others in vari ...
JUL 11, 2020
Cancer
New drug combo could improve immunotherapy for SCCOHT ovarian cancer
JUL 11, 2020
New drug combo could improve immunotherapy for SCCOHT ovarian cancer
Research published recently in PLOS ONE reports on SP-2577, a drug that could help girls and young women plagued with a ...
JUL 24, 2020
Cancer
A New Biomarker Candidate for Cancer Diagnostics
JUL 24, 2020
A New Biomarker Candidate for Cancer Diagnostics
One of the best tools in the fight against cancer is diagnostics. In 2018, colorectal cancer was the second most lethal ...
JUL 29, 2020
Cancer
Regulating Apoptosis in Prostate Cancer
JUL 29, 2020
Regulating Apoptosis in Prostate Cancer
Cancer treatments tend to work in one of a few ways. They can target the immune system, prevent cancer proliferation and ...
JUL 30, 2020
Cancer
Researchers say DBT doesn't serve women with "extremely dense" breasts
JUL 30, 2020
Researchers say DBT doesn't serve women with "extremely dense" breasts
When you undergo screening for breast cancer, you usually have to have a mammogram, an x-ray that looks for abnormal mas ...
AUG 05, 2020
Cancer
A New Test to Analyze Cell-Free DNA in Cancer Diagnostics
AUG 05, 2020
A New Test to Analyze Cell-Free DNA in Cancer Diagnostics
Cell-free DNA (cfDNA) are small pieces of genomic DNA that have escaped into the bloodstream either through active relea ...
Loading Comments...