SEP 15, 2020 9:21 AM PDT

Soy helps post-op treatment of bone cancer

New research published in the journal Acta Biomaterialia highlights the post-operative benefits of soy in treatment for bone cancer. While previous studies have suggested that soy is associated with reduced risk of cardiovascular disease, obesity, and cancer, as well as improved bone health, Washington State University scientists say that soy may also help patients during post-op chemotherapy.

Osteosarcoma, which affects mostly young people, is the second leading cause of cancer death in children. Standard treatment includes surgery to remove the tumor in addition to pre- and post-operative chemotherapy. The treatment is harsh and patients frequently have a lot inflammation from the surgery and bone reconstruction, in addition to the harmful side effects of chemotherapy. Unfortunately, osteosarcoma and metastatic bone cancer patients also often have a high rate of recurrence.

Led by WSU's School of Mechanical and Materials Engineering researchers Professor Susmita Bose and Naboneeta Sarkar, the study analyzed the effects of soy-based chemical compounds released slowly during chemotherapy. The goal of this treatment is to reduce inflammation. The team has taken a materials science angle in their research in order to develop biomedical devices that could be useful during cancer treatment.

"There is not much research in this area of natural medicinal compounds in biomedical devices," Bose said. "Using these natural medicines, one can make a difference to human health with very minimal or no side effects, although a critical issue remains composition control."

Soybeans have been spotlighted because of the beneficial properties of the compounds in them called isoflavones. These plant-derived estrogens are toxic to certain types of cancer cells while simultaneously not harmful to healthy cells. They have also been associated with bone health.

Photo: Pixabay

In conducting their research, the scientists 3D printed patient-specific, bone-like scaffolds composed of three soy compounds. They then used sample bone cancer cells and healthy cells to test a slow-release of the compounds into the cells. They found that while all three soy compounds reduced inflammation, two in particular significantly improved the growth of healthy bone cells and one resulted in a 90% reduction in bone cancer cell viability after only 11 days.

"These results advance our understanding in providing therapeutic approaches in using synthetic bone grafts as a drug delivery vehicle," Bose said. The team plans to continue their research in order to better understand the specific pathways of the genetic expression of soy.

Sources: Acta Biomaterialia, Eureka Alert

About the Author
  • Kathryn is a curious world-traveller interested in the intersection between nature, culture, history, and people. She has worked for environmental education non-profits and is a Spanish/English interpreter.
You May Also Like
SEP 02, 2021
Cancer
When Cholesterol Doesn't Kill Cancer, it Makes it Stronger!
SEP 02, 2021
When Cholesterol Doesn't Kill Cancer, it Makes it Stronger!
High cholesterol is associated with an increased risk of several types of cancer, and cancer patients with high choleste ...
SEP 06, 2021
Drug Discovery & Development
Antibiotics Increase Colon Cancer Risk by 17%
SEP 06, 2021
Antibiotics Increase Colon Cancer Risk by 17%
People who take antibiotics are at an increased risk of developing colon cancer within five to ten years. The research w ...
SEP 23, 2021
Drug Discovery & Development
The FDA approves the first and only oral treatment for a certain non-small cell lung cancer.
SEP 23, 2021
The FDA approves the first and only oral treatment for a certain non-small cell lung cancer.
Last week, the United States Food and Drug Administration (FDA) granted approval for the first oral therapy to ...
OCT 14, 2021
Immunology
'Bio-Betters' Form the Next Wave of Cancer Therapies
OCT 14, 2021
'Bio-Betters' Form the Next Wave of Cancer Therapies
  Antibodies are blood proteins with highly specialized functions: to recognize and eliminate bacteria, viruses, an ...
OCT 24, 2021
Microbiology
New Treatment Approach Uses Bacteria to Deliver Drugs to Cancer Cells
OCT 24, 2021
New Treatment Approach Uses Bacteria to Deliver Drugs to Cancer Cells
Bacteria can be found almost everywhere, and they can serve many beneficial purposes. Scientists are now using bacterial ...
NOV 10, 2021
Cannabis Sciences
Does Cannabis Use Reduce the Risk of Cancer?
NOV 10, 2021
Does Cannabis Use Reduce the Risk of Cancer?
In medical terminology, there are few terms as imposing as ‘cancer.’ According to the Centers for Disea ...
Loading Comments...