MAR 31, 2016 11:27 AM PDT

Pill Lights Up Breast Cancer Lumps for Easier Detection

WRITTEN BY: Xuan Pham
This year, doctors will diagnose over 240,000 new cases of breast cancer in women. Mammograms have been the standard first line of defense in breast cancer detection, but not every lump points to cancerous origins. Getting the right diagnosis is crucial to prevent unnecessary treatments, and a new pill that lights ups breast cancer cells could help doctors better make this call.
 
“There’s a lot of controversy right now about when patients should start screening for breast cancer,” said Greg Thurber, senior investigator. “Screening can potentially catch the disease early in some patients, but false positives can lead to unnecessary, aggressive treatments in patients who don’t need them. We don’t know how to select the right patients to treat. Our work could help change that.”
 
At the 251st National Meeting & Exposition of the American Chemical Society (ACS), researchers from the University of Michigan announced a pill that selectively fluoresces breast cancer tissues in mice. It works by binding to cancer cells or blood vessels unique to breast tumors. Then, under near-infrared light the pill causes cancer tissues to fluoresce, taking the guesswork out of determining whether a lump is malignant or actually benign.
 

In a standard mammography screen, X-ray radiation reveals the presence, location, and size of lumps in breast tissues that otherwise can’t be detected by touch alone. Even so, one drawback of mammography is it can lead to breast cancer false-positives, as the presence of a lump can’t indicate cancer with certainty. Often, doctors have to further validate mammography findings via invasive biopsies. The light-up pill could change how mammography results are read, and thus relieve some patients of needless procedures.

Breast cancer tumors light up with infrared lightIn a mouse model of breast tumor, the team found that the pill significantly absorbed into the bloodstream – at 50-60 percent – and that it selectively highlighted breast cancer tissues. In contrast, there was little activity in the surrounding background tissues, indicating a high binding specificity.
 
For the next phase, Thurber and his team are working to modify the formula, making it suitable for human clinical trials. Additionally, the team aims to enhance detection of not only breast cancer, but to differentiate between different sub-types of breast cancers with the pill. Knowing which types are slow-growing or invasive could allow doctors to further tailor therapies for their patients. While clinical trials could be a long way in the future, Thurber noted that they dye is already in use in Europe. 

Additional source: ACS press release
About the Author
  • I am a human geneticist, passionate about telling stories to make science more engaging and approachable. Find more of my writing at the Hopkins BioMedical Odyssey blog and at TheGeneTwist.com.
You May Also Like
APR 14, 2021
Clinical & Molecular DX
AI-Powered Imaging System Can Tell If a Patient Is Cancer-Free
APR 14, 2021
AI-Powered Imaging System Can Tell If a Patient Is Cancer-Free
A patient undergoes chemotherapy and radiation for rectal cancer. How do doctors know whether all the malignant tissue h ...
APR 25, 2021
Genetics & Genomics
How Did the Chernobyl Disaster Affect Human Health?
APR 25, 2021
How Did the Chernobyl Disaster Affect Human Health?
It's been about 35 years since the disaster at the Chernobyl nuclear power plant. Now researchers have investigated whet ...
MAY 05, 2021
Immunology
Novel 3D Bio-printed Leukemia Model Shows Potential for Treatment Testing Platform
MAY 05, 2021
Novel 3D Bio-printed Leukemia Model Shows Potential for Treatment Testing Platform
Three-dimensional (3D) printing has become a common technique over the past two decades. Now, the technique has been ado ...
MAY 13, 2021
Immunology
Tumors Hide From the Immune System by Masquerading as Baby Cells
MAY 13, 2021
Tumors Hide From the Immune System by Masquerading as Baby Cells
The immune system is programmed to recognize foreign bodies as potentially dangerous, promptly removing them before the ...
MAY 02, 2021
Cancer
Evaluating early learning skills in child survivors of retinoblastoma
MAY 02, 2021
Evaluating early learning skills in child survivors of retinoblastoma
A report published recently in the Journal of Clinical Oncology highlights the need for early intervention resources for ...
JUN 09, 2021
Clinical & Molecular DX
Faster, Cheaper Diagnosis of Rare Cancer in Fat Cells
JUN 09, 2021
Faster, Cheaper Diagnosis of Rare Cancer in Fat Cells
Scientists have created a gene panel test to quickly and more precisely diagnose common forms of liposarcoma. This break ...
Loading Comments...