AUG 25, 2016 8:44 AM PDT

Scientists Reveal How Melanoma Spreads from Skin to Organs

WRITTEN BY: Xuan Pham
The unpredictable progression of melanoma makes it one of the most deadly form of skin cancers. Now researchers say they’ve identified a mechanism behind how melanoma metastasizes. In particular, to migrate from the epidermis to the rest of the body, melanoma cells appear to send out microRNA-containing vesicles to prep tissues for the cancer’s incoming assault. Knowing this mechanism could open the door for possible new drug targets for this disease.

How melanoma spreads to other organs in the body | Image: Wellcome Images

Melanoma is a deadly form of skin cancer caused by ultraviolet radiation damages to the skin cells. According to the World Health Organization, between 2 and 3 million people worldwide have skin cancer. And of that, about 132,000 people have melanoma. The incidence of skin cancer is only rising, as experts believe the depletion of the ozone layer will result in an additional 300,000 new cases every year.

"The threat of melanoma is not in the initial tumor that appears on the skin, but rather in its metastasis -- in the tumor cells sent off to colonize in vital organs like the brain, lungs, liver and bones," said Carmit Levy, senior research author and professor the Department of Human Molecular Genetics and Biochemistry at Tel Aviv. "We have discovered how the cancer spreads to distant organs and found ways to stop the process before the metastatic stage."

Melanoma first attacks the epidermis of the skin – the outermost layer that protects us against the environment. But how does the cancer spread to other parts of the body when the epidermis contains no blood vessels?  

To answer this question, the team dissected the nitty gritty details of skin morphology starting at the earliest stage of cancer. "We looked at samples of early melanoma, before the invasive stage," said Levy. "To our surprise we found changes in the morphology of the dermis -- the inner layer of the skin -- that had never before been reported. Our next task was to find out what these changes were, and how they related to melanoma."
 

Upon further investigation, they found the melanoma cells were cunning enough to prep the other tissues for its subsequent attack. "We found that even before the cancer itself invades the dermis, it sends out tiny vesicles containing molecules of microRNA," Dr. Levy said. "These induce the morphological changes in the dermis in preparation for receiving and transporting the cancer cells. It then became clear to us that by blocking the vesicles, we might be able to stop the disease altogether."

Indeed, when the team then found two chemicals that fit the bill. One chemical (SB202190) blocked the melanoma from sending out microRNA vesicles, while another (U0126) blocked the effects of the vesicles in the dermis. So far, lab experiments show promise for the individual drug candidates. However, it could still be years before these compounds enter clinical trials for human treatment.

"Our study is an important step on the road to a full remedy for the deadliest skin cancer," said Dr. Levy. "We hope that our findings will help turn melanoma into a nonthreatening, easily curable disease."

Additional source: Tel Aviv University
About the Author
  • I am a human geneticist, passionate about telling stories to make science more engaging and approachable. Find more of my writing at the Hopkins BioMedical Odyssey blog and at TheGeneTwist.com.
You May Also Like
JUN 04, 2020
Cancer
Inhibiting the Signals Critical for Cancer Growth in Merkel Cell Carcinoma
JUN 04, 2020
Inhibiting the Signals Critical for Cancer Growth in Merkel Cell Carcinoma
Merkel Cell Carcinoma (MCC) is a highly aggressive cancer of the skin. It is characterized by a high recurrence rate and ...
JUN 16, 2020
Cancer
Wearable patch for melanoma patients
JUN 16, 2020
Wearable patch for melanoma patients
Research published in the journal ACS Nano describes a wearable patch that can be used to lessen side effects from chemo ...
JUN 22, 2020
Cancer
Black patients are underrepresented in clinical trials
JUN 22, 2020
Black patients are underrepresented in clinical trials
Amidst the swell of racial injustice that the country is bringing to light, new research reports that Black patients are ...
JUL 20, 2020
Cancer
Fighting Cancer with Black Pepper
JUL 20, 2020
Fighting Cancer with Black Pepper
In the never-ending search for the next treatment or cure, many researchers turn towards nature. The study of black pepp ...
JUL 24, 2020
Cancer
A New Biomarker Candidate for Cancer Diagnostics
JUL 24, 2020
A New Biomarker Candidate for Cancer Diagnostics
One of the best tools in the fight against cancer is diagnostics. In 2018, colorectal cancer was the second most lethal ...
JUL 30, 2020
Cancer
Researchers say DBT doesn't serve women with "extremely dense" breasts
JUL 30, 2020
Researchers say DBT doesn't serve women with "extremely dense" breasts
When you undergo screening for breast cancer, you usually have to have a mammogram, an x-ray that looks for abnormal mas ...
Loading Comments...