JUN 23, 2017 11:58 AM PDT

Simple Blood Test Could Improve Colon Cancer Outcomes

WRITTEN BY: Xuan Pham

A blood test that’s been around for decades might have the potential to improve treatment for thousands of colon cancer patients.

Image credit: Pixabay.com

Colon cancer, also known as colon cancer or bowel cancer, is the third most common non-skin cancer type in the world. The cancer usually begins as small, benign lumps of cells that form polyps in the colon. Without proper removal, these polyps can turn cancerous and cause symptoms such as abdominal pain, rectal bleeding, weakness, and fatigue. According to a recent report, the incidence of colorectal cancer is expected to increase by 60% to more than 2.2 million new cases and 1.1 million deaths by 2030.

Knowing the type of colon cancer profile of individual patients could make a tremendous impact in their outcomes. As such, researchers from the Mayo Clinic scoured the National Cancer Database for colon cancer information on close to 41,000 patients. They found that a biomarker, known as carcinoembryonic antigen (CEA) can help doctors reclassify stage 2 colon cancer patients from average risk to high risk.

"The decision to give a patient chemotherapy after surgery is not a light one, and physicians must weigh the risks and benefits," said Kellie Mathis, a Mayo Clinic colon and rectal surgeon, and the study’s senior author. "We are currently using the blood test to help make these difficult decisions, and we suggest other physicians do the same."

By correctly classifying stage 2 colon cancer patients as high risk, doctors are able to guide patients to more appropriate therapies. And this may mean the use of chemotherapy. The team found that for patients with high levels of CEA, the five-year survival rate was lower (66 percent) as compared to those without elevated levels of CEA (76 percent). However, those with elevated CEA and chemotherapy in conjunction with surgery seemed to have better outcomes than surgery alone.

The blood test also saves stage 2, low-risk colon cancer patients from having to endure chemotherapy treatments.

"There is no good reason for a physician to omit this blood test, and more work needs to be done to ensure that all patients receive it," said Dr. Mathis. "If a patient with a new diagnosis of stage 2 colon cancer has an elevated carcinoembryonic antigen level, physicians should consider chemotherapy in addition to surgery.”

The blood test for CEA is currently not used for the stratification of stage 2 colon cancer. Rather, this test is performed after a patient’s surgery, for monitoring purposes. But if performed at the onset, the researchers argue the results of this test would better inform physician decision on colon cancer treatment.

Additional source: Mayo Clinic

About the Author
  • I am a human geneticist, passionate about telling stories to make science more engaging and approachable. Find more of my writing at the Hopkins BioMedical Odyssey blog and at TheGeneTwist.com.
You May Also Like
SEP 14, 2020
Genetics & Genomics
Why Defects in One Gene Can Lead to Cancer in Kids
SEP 14, 2020
Why Defects in One Gene Can Lead to Cancer in Kids
While they may occur in adults, a rare, aggressive type of brain cancer called atypical teratoid rhabdoid tumors tend to ...
SEP 14, 2020
Cancer
We are too uneducated on the risks of colon cancer
SEP 14, 2020
We are too uneducated on the risks of colon cancer
A study conducted by researchers from Florida Atlantic University's Schmidt College of Medicine suggests that too ma ...
SEP 18, 2020
Coronavirus
How Coronavirus Spread in the US and Europe
SEP 18, 2020
How Coronavirus Spread in the US and Europe
Researchers are beginning to examine how the world's response to the pandemic virus SARS-CoV-2 went wrong, and right ...
OCT 05, 2020
Cancer
Fighting mitochondrial terminal exhaustion
OCT 05, 2020
Fighting mitochondrial terminal exhaustion
New findings reported in Nature Immunology highlight how the tumor microenvironment attacks the mitochondria of T l ...
OCT 11, 2020
Cancer
Targeting neoantigens to improve immunotherapies
OCT 11, 2020
Targeting neoantigens to improve immunotherapies
Neoantigens are extremely small biomarkers forming from cancer mutations that demonstrate the presence of cancerous cell ...
NOV 09, 2020
Cancer
A Prognostic Expression Profile for Osteosarcoma
NOV 09, 2020
A Prognostic Expression Profile for Osteosarcoma
Tireless research goes into every cancer diagnostic tools and new therapy. Many types of cancer have made giant steps fo ...
Loading Comments...