DEC 31, 2015 03:55 AM PST

Newest Therapy for Heart Failure Utilizes Asynchronous Electrical Shocks

WRITTEN BY: Kara Marker
Millions of Americans suffer from heart failure, a debilitating condition that develops when the heart loses its ability to properly pump blood, oxygen, and nutrients to the body tissues. An innovative therapy is currently being studied at John Hopkins University to reverse the effect of heart failure, and their most recent results were published in Science Translational Medicine.

The therapy, called “Pacemaker Induced Transient Asynchrony” (PITA), uniquely shocks the heart into an asynchronous rhythm and back to a synchronous rhythm in order to delay heart failure progression.
Successful clinical experiments in dogs were conducted by John Hopkins scientists to test PITA’s ability to “reverse cellular damage to the heart’s response to hormones and fix the damage to the motor proteins in the heart that generate force.”

Researchers induced heart failure in 23 animal subjects; 10 received PITA therapy and 13 did not. These 13 subjects served as heart failure controls. In addition, eight subjects were controls not induced with heart failure.

After four weeks of PITA treatment, the researchers observed “reduced progressive enlargement of the heart” in the group of 10 subjects in comparison to the group of 13 who did not receive PITA. In addition, the group receiving PITA treatment showed enhanced response to adrenaline hormones by 38 percent. Other improvements include reversal of motor protein structural damage and dysfunction and muscle force stability.

"We're very excited about prospects for this therapy because if further research confirms its effectiveness and safety, it's relatively easy to implement,” said John Hopkins University School of Medicine David Kass, MD. “The pacemaker hardware already exists, and with some software upgrades, we may have a treatment that would benefit many, many people.”

It seems counterintuitive to treat a patient with heart failure with asynchronous electrical shocks, but Kass describes the treatment’s effectivity to immunization. With the right amount of asynchrony, the heart can be tuned back to normal synchrony just like exposing the immune system to parts of a pathogen can prepare it for future infections.

Further studies will help scientists determine the suitability of this experimental treatment for clinical use in heart failure patients, a condition that 5.7 million Americans currently live with (American Heart Association).  So far, there have been no adverse side effects observed with PITA.

Watch the following video to learn more about how a pacemaker controls the heartbeat:

Source: John Hopkins University
 
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
OCT 16, 2019
Cell & Molecular Biology
OCT 16, 2019
A Test to Measure the Effectiveness of Stem Cell Transplantation
Stem cells-based therapies may one day repair disorders caused by damaged cells. But those therapeutics must be tested....
OCT 16, 2019
Cardiology
OCT 16, 2019
TAVR Procedure Shares Spotlight With Rock Legend
While legendary rockstar Mick Jagger recently underwent a Transcatheter Aortic Valve Replacement (TAVR) at a hospital in New York, many are not candidates...
OCT 16, 2019
Cardiology
OCT 16, 2019
Vary Fitness Routine To Avoid Injury
For regular exercisers, overuse injuries are a common development. These are the most common types of injuries in sport. Examples include Runner’s kn...
OCT 16, 2019
Cardiology
OCT 16, 2019
Heart Conditions Amongst The Most Misdiagnosed
There are a massive number of diseases that a person can acquire. This can make the idea of diagnosing a disease accurately seem like a daunting task. Shoc...
OCT 16, 2019
Cardiology
OCT 16, 2019
Poor U.S. Counties Have More Heart Failure Deaths
In 2009, one in nine U.S. deaths included heart failure as contributing cause, according to the Centers for Disease Control (CDC). And about half of the pe...
OCT 16, 2019
Cardiology
OCT 16, 2019
Your Brain On Cardiovascular Exercise
There is an increasing number of studies that explore the connection between exercise and the brain. These studies have revealed some fascinating connectio...
Loading Comments...