SEP 13, 2016 7:50 PM PDT

Optical Defibrillation of the Heart: Making It Possible

WRITTEN BY: Kara Marker
An international team of scientists is on the cutting edge of a new treatment for cardiac arrhythmia that uses light beams instead of electricity to restore the heart’s healthy beat. 
Source: MedtronicEurope
The new method of creating implantable defibrillators based on light works through optogenetics: installing light-sensitive proteins in living tissue to enable light sources to modify the electrical activity in cells, like cardiomyocytes, the muscle cells of the heart. Using light instead of electric shocks to treat arrhythmia, doctors could bypass the pain and potential damage to heart tissue for their patients. 

“Light will be given to a patient who is experiencing cardiac arrest, and we will be able to restore the normal functioning of the heart in a gentle and painless manner," explained Natalia Trayanova, PhD from Johns Hopkins University. Trayanova teamed up with researchers from the University of Bonn in Germany to test the new technology, starting with a Germany-based test in mice models of disease.

Researchers from the University of Bonn initially tested the light-sensitive defibrillators on beating mouse hearts whose cardiomyocytes had been genetically altered to express light-sensitive proteins. After triggering ventricular fibrillation, a light pulse one second-long successfully restored normal rhythm.

Meanwhile at Johns Hopkins, Trayanova and her team set out to see if the methodology from the Germany study in mice worked the same in humans. They conducted the same experiment except with a computer model of the human heart derived from MRI scans from an actual arrhythmia patient recovering from a heart attack rather than mice with arrhythmias. 

Successful results where light beams corrected arrhythmias were obtained after some alterations were made to the original method. Red light was used instead of blue light for defibrillation because of its longer wavelength that is more powerful, a strength that was needed to penetrate human heart tissue. 

In addition, Trayanova said that the “simulations revealed the precise ways in which light alters the collective electrical behavior of the cells in the heart to achieve the desired arrhythmia termination.”

More time and research is needed until this procedure can become “commonplace” in medicine; researchers estimate at least five to ten years.

The study was published in The Journal of Clinical Investigation.
 


Source: Johns Hopkins University

 
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
JUN 24, 2021
Technology
New Hydrogel Designed to Prevent Post-surgical Heart Tissue Adhesions
JUN 24, 2021
New Hydrogel Designed to Prevent Post-surgical Heart Tissue Adhesions
Nearly 20% of cardiac surgery patients will require another operation at some point in the future. This is especially tr ...
JUN 28, 2021
Cardiology
The Electricity of a Beating Heart is Caught on Graphene Camera
JUN 28, 2021
The Electricity of a Beating Heart is Caught on Graphene Camera
When graphene was first developed, it was hailed as a revolutionary material but its potential uses seemed unclear to ma ...
JUN 30, 2021
Clinical & Molecular DX
A Deep Learning Tool for Faster, Better Heart Disease Diagnoses
JUN 30, 2021
A Deep Learning Tool for Faster, Better Heart Disease Diagnoses
A new deep learning tool could help slash the time it takes to interpret cardiology scans to diagnose obstructive corona ...
AUG 03, 2021
Health & Medicine
Viruses and Autoimmunity: What Pandemics Have Taught Us
AUG 03, 2021
Viruses and Autoimmunity: What Pandemics Have Taught Us
COVID-19 infections have given rise to COVID long haulers, people who had COVID and continue to have symptoms months aft ...
AUG 25, 2021
Cardiology
Don't Underestimate the Importance of the Spleen
AUG 25, 2021
Don't Underestimate the Importance of the Spleen
The spleen is one of the organs we can live without, but researchers are increasingly recognizing its importance. We kno ...
NOV 19, 2021
Technology
Artificial Intelligence Could Predict Risk of Atrial Fibrillation
NOV 19, 2021
Artificial Intelligence Could Predict Risk of Atrial Fibrillation
Atrial fibrillation (AF) is a common heart condition—by 2030, the Centers for Disease Control estimates that nearl ...
Loading Comments...