DEC 27, 2016 6:52 PM PST

New Experimental Drug To Mend Heart Failure

WRITTEN BY: Kara Marker

Cimaglermin, a new drug under investigation, could be the future of cardiovascular medicine. A new study from scientists at Vanderbilt show the possibility of the drug for the restoration of cardiac function after heart failure, a leading cause of death for Americans.

Source: www.abouthf.org

More often than not, heart failure patients with severe left ventricular systolic dysfunction in particular do not respond well to current methods of treatment, which led researchers to cimaglermin as an alternative.

Led by Vanderbilt’s Daniel L. Lenihan, MD, researchers conducted a study with 40 heart failure patients who had all been receiving optimal medical therapy post-heart failure for at least three months before they entered the trial and began receiving cimaglermin. However, the researchers only examined the effects on safety and efficacy for a single dose of cimaglermin.

Compared to control participants who were just given a placebo, participants who received the single infusion of cimaglermin showed a substantial increase in pumping capacity, measured in terms of left ventricular ejection fraction. While still an experimental drug, cimaglermin was already being shown to boost the natural mechanisms for repairing all aspects of heart: structural, metabolic, and contractile elements.

“Instead of blocking the fundamental mechanisms that lead to cardiac injury, the early results with cimaglermin suggest that it may also be possible to administer therapeutics that allow the failing heart to repair itself using its own repair mechanisms,” explained Douglas L. Mann, MD, FACC, editer-in-chief of JACC: Back to Translational Science. The current study showed that the most common side effects of the drug were nausea and headaches.

“As with all experimental therapeutics, additional studies will be required and subject to regulatory review to determine if the relative risks and benefits of cimaglermin warrant approval,” said Lenihan. Studies will continue with more participants and more doses of the drug.

Lenihan’s study was recently published in the journal JACC: Basic to Translational Science.

Sources: Vanderbilt University, American College of Cardiology

About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
DEC 03, 2020
Chemistry & Physics
3-D Printed, Realistic Heart Model for Training Future Physicians
DEC 03, 2020
3-D Printed, Realistic Heart Model for Training Future Physicians
Building a realistic tissue model is critical for training young physicians and surgeons, and yet challenging due to the ...
JAN 14, 2021
Cardiology
Cortisol in Your Hair Could Predict Your Risk of Heart Attack
JAN 14, 2021
Cortisol in Your Hair Could Predict Your Risk of Heart Attack
The everyday tracking of health has become far easier these days with the advent of fitness watches and other technology ...
MAR 30, 2021
Cardiology
Looking at a Fertility Drug's Cardiac Safety
MAR 30, 2021
Looking at a Fertility Drug's Cardiac Safety
New drugs go through a long and arduous process before they can grace a doctor’s office. One of the last steps is ...
APR 13, 2021
Cardiology
Can a Ketosis Metabolite Act as a Biomarker for Cardiovascular Diseases?
APR 13, 2021
Can a Ketosis Metabolite Act as a Biomarker for Cardiovascular Diseases?
Quick and reliable diagnostics are the key to controlling many diseases, including cardiovascular disease. Biomarkers ar ...
MAY 03, 2021
Health & Medicine
Want to Become a Better Runner? Get More Sleep.
MAY 03, 2021
Want to Become a Better Runner? Get More Sleep.
Want to get the most out of your workout routine? Don't skimp on sleep, especially if you're focusing on enduran ...
JUL 16, 2021
Cardiology
Therapeutic Exosome Spray May One Day Aid Heart Attack Recovery
JUL 16, 2021
Therapeutic Exosome Spray May One Day Aid Heart Attack Recovery
When the flow of blood to the heart is blocked, heart cells don't get enough oxygen and begin to die; this is a heart at ...
Loading Comments...