JUN 20, 2017 3:35 PM PDT

Fetal DNA Raises Risk of Mother's Pre-Eclampsia

WRITTEN BY: Kara Marker

For the first time, researchers report that a baby’s DNA influences a mother’s risk of pre-eclampsia, a condition that affects about five percent of pregnancies. From the University of Nottingham, scientists examine the genetic profiles of more than four thousand babies born from pre-eclamptic pregnancies to understand the complexity of the connection.

A five-year study called InterPregGen analyzed DNA from 4,380 pre-eclamptic-born babies in comparison to DNA from 300,000 babies born from normal pregnancies. The results indicated a specific location in a baby’s DNA that increases a mother’s risk of pre-eclampsia.

Pre-eclampsia is a dangerous condition affecting pregnant women and is associated with the faulty formation of the placenta. Complications from pre-eclampsia include stroke, liver, blood problems, and sometimes death for the other and/or the baby. High blood pressure during the second half of the pregnancy is often a precursor to pre-eclampsia, which is also associated with family history of the disease, both maternal and paternal.

“As it is the baby's genes that produce the placenta we set out to see if we could find a link between the baby's DNA and the condition,” explained Dr. Linda Morgan, coordinator of the study. “We found there were indeed some features in a baby's DNA that can increase the risk of pre-eclampsia."

DNA variations nearby to a gene that produces a protein called sFlt1 was found to be linked to pre-eclampsia risk. High levels of sFlt1 expression originating in the placenta and ending up in the mother’s blood is responsible for high blood pressure and damaged kidneys, liver, and brain, Morgan found. This information could be largely helpful for predicting which mothers are at high risk of pre-eclampsia, through analyzing family history and genetic information.

“This first piece of the genetic jigsaw holds substantial promise for unlocking some of the mystery of how pre-eclampsia is caused,” said study researcher Dr. Ralph McGinnis.

“Now modern genome wide screening and its data analysis allows us to look for clues in the mother's, father's and their baby's DNA,” Morgan said. “We believe the new insights from this study could form the basis for more effective prevention and treatment of pre-eclampsia in the future, and improve the outcome of pregnancy for mother and child."

Next, Morgan plans on conducting new studies using DNA from 4,220 different babies from pre-eclamptic pregnancies, specifically focused on sFlt-1 variations.

The present study was published in the journal Nature Genetics.

Source: University of Nottingham

About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
DEC 08, 2020
Cardiology
Some Stroke Risk Disparities May be Linked to Heart Structure
DEC 08, 2020
Some Stroke Risk Disparities May be Linked to Heart Structure
Scientists have found that there are structural differences in the heart's left atrium in Black and white people, an ...
APR 06, 2021
Cardiology
In 2020, Deaths in the US Were Over 20% Higher Than Typical Years
APR 06, 2021
In 2020, Deaths in the US Were Over 20% Higher Than Typical Years
Researchers have begun to analyze the impact of the pandemic, and their work has shown that long COVID-19 surges in the ...
APR 14, 2021
Cardiology
Activity At Work Doesn't Benefit Like Leisure Time Exercise
APR 14, 2021
Activity At Work Doesn't Benefit Like Leisure Time Exercise
A new study that examined the habits and health conditions of thousands of people has suggested that exercise that's don ...
APR 20, 2021
Cardiology
Does Impaired Glucose Tolerance Increase Heart Damage After a Stroke?
APR 20, 2021
Does Impaired Glucose Tolerance Increase Heart Damage After a Stroke?
Diabetes is a looming threat to the world’s healthcare systems. Diagnoses of its precursors, impaired glucose tole ...
JUN 15, 2021
Cardiology
A Common Thread Among 20% of Sudden Cardiac Deaths
JUN 15, 2021
A Common Thread Among 20% of Sudden Cardiac Deaths
It's estimated that 450,000 Americans die from sudden heart conditions, and in about one in ten cases, the cause is unex ...
JUL 16, 2021
Technology
Echocardiogram May Help Predict COVID-19 Patients at Risk for Heart Complications
JUL 16, 2021
Echocardiogram May Help Predict COVID-19 Patients at Risk for Heart Complications
Researchers learned early on in the pandemic that COVID-19 infections caused a range of complications throughout the bod ...
Loading Comments...