JAN 02, 2018 2:48 PM PST

Scientists Have A New, Better Way to Measure "Bad" Cholesterol

WRITTEN BY: Kara Marker

High levels of “bad” cholesterol, also known as low-density lipoprotein (LDL), is a well-known risk factor for all kinds of heart disease. For decades, scientists have used an approach called the Friedewald method to measure LDL, but now Johns Hopkins scientists have a better, more accurate approach that no longer requires patients to fast the night before.

By measuring levels of LDL in the blood with better accuracy than ever before, scientists can identify individuals who might be at risk of heart disease. LDL levels over 70 milligrams per deciliter indicates a person’s risk of adverse cardiac events like heart attack and arrhythmias. And by dismissing the need for fasting the night before an LDL blood test, medical professionals can conduct more convenient cholesterol screenings.

"Although the new LDL calculation method is a bit more complex, the beauty is that it can be performed using information that is already collected in the blood sample for the standard lipid profile and automated in the lab's computer system to give a more accurate result," explained Seth Martin, MD, MHS, who developed the new method alongside colleagues from Johns Hopkins University.

As the traditional approach to calculating cholesterol, the Friedewald method requires fasting blood samples for optimal accuracy. This method calculates LDL by measuring total cholesterol and then subtracting “good” cholesterol, or high-density lipoprotein (HDL). However, the Friedewald method does not consider differences among individual patients.

The new method does take into account individual variation, with a chart of 180 different factors for those using the test to better measure LDL at not extra time or cost. In 2013, Johns Hopkins researchers found that the Friedewald method underestimates LDL levels, especially for participants with high triglycerides, which are higher in people with obesity and diabetes.

In the new study, using data from over 1.5 million people in the United States, researchers found that LDL calculation from non-fasting data was 92 percent accurate using the new Johns Hopkins method compared to 71 percent using the Friedewald method.

However, for some patients at an especially high risk of heart disease, fasting before a cholesterol blood test is still important, considering the high value of the test’s utmost accuracy for deciding treatment approaches.

"Some patients can have sizable changes in triglycerides after eating, and that is what makes the older Friedewald method less accurate for these people because this isn't taken into account and it exaggerates the underestimation problem of LDL levels," explained Vasanth Sathiyakumar, MD. "One of the strengths of our analysis is that we don't look at average responses but rather look at each participant's personalized levels using 180 different factors to determine a more accurate calculation."

The present study was published in the journal Circulation.

Sources: Atherosclerosis, Johns Hopkins Medicine

About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
JAN 15, 2020
Cardiology
JAN 15, 2020
Women's Blood Vessels Age Faster than Men's, Study shows
Around 75 million Americans have high blood pressure, or roughly 1 in every 3 adults. Now, new research has shown that w ...
JAN 17, 2020
Cardiology
JAN 17, 2020
Toxic Metals and Cardiovascular Risk
A meta-analysis was recently published in the British Medical Journal to try and understand if there was a link between ...
FEB 10, 2020
Cardiology
FEB 10, 2020
Blocking Problem Protein Shows Promise for Preventing Heart Attacks
Over time, atherosclerosis, a disease that causes fatty plaques to build up in the arteries, limits the flow of oxygen-r ...
MAR 29, 2020
Cardiology
MAR 29, 2020
Coronavirus Damages Heart Tissue, Not Just the Lungs
Although most severe cases of the novel coronavirus involve respiratory failure, new research has found that the virus m ...
APR 23, 2020
Health & Medicine
APR 23, 2020
Study Shows Filtered Coffee is Best for Your Health
Are you drinking more coffee than usual during the COVID-19 lockdown? Navigating weeks of working from home or onsite, a ...
APR 16, 2020
Technology
APR 16, 2020
Technology Lights The Way For Safer Imaging Techniques
Current imaging techniques rely on the possibility of harmful radiation. To challenge that, researchers at John Hopkins ...
Loading Comments...