FEB 20, 2018 6:06 AM PST

Newly Discovered Gene Helps Blood Vessels Grow

WRITTEN BY: Kara Marker

Many types of heart disease and stroke stem from a poor supply of blood to important tissues and organs. A new discovery from St. Michael’s Hospital underscores a way to make up for this deficiency. Scientists introduce a new gene: STEEL.

A cross-section of a blood vessel, with the different protective layers evident. Credit: Josef Reischig, CSc.

STEEL stands for "spliced-transcript endothelial-enriched long non-coding RNA.” This is a highly technical term that essentially means that STEEL is a type of gene called a long non-coding RNA (lncRNA) that is uniquely enriched with endothelial cells, which line the inside of blood vessels. A population of endothelial cells makes up a protective layer called the endothelium, which exist from the largest arteries and veins to the smallest capillaries.

Researchers were studying lncRNAs when they made the STEEL discovery. lncRNAs are a large and diverse type of RNA, a type of genetic material found in every cell in the body. For a long time, scientists believed RNA’s only role was to bring information from genes to DNA to make proteins. This is an RNA role, but it’s not their only role. As scientists learn more and more about lncRNAs, they learn that RNAs are also involved in determining the function fulfilled by individual cells in an organism.

The study’s purpose was to evaluate and pinpoint specific lncRNAs that are more enriched with endothelial cells than other cell types. When they identify the right lncRNAs they plan to make the information available for other researchers to use, for scientists also studying blood vessels or for those who are just studying lncRNAs in general. While there are several specialized lncRNA databases, lncRNA research is still in its infancy.

Compared to other lncRNAs, they found that STEEL most effectively sensed inadequate blood flow in extremely small blood vessels. Even more, STEEL helps the body respond to the deficiency by triggering the growth of more blood vessels, a process called angiogenesis.

"These results show that our bodies are really finely tuned to perform, just as we need them to, and also demonstrate that disruptions to this fine balance can cause problems,” explained co-lead scientist Dr. Jeffrey Man from St. Michael’s Hospital. “This data can be used to improve our understanding of blood vessel diseases and help us find ways to improve healing and recovery after injury."

The present study was published in the journal Proceedings of the National Academy of the Sciences.

Sources: Exiqon, Molecular Biology of the Cell, 4th edition, St. Michael’s Hospita

About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
FEB 24, 2021
Cardiology
Drinking Lots of Unfiltered Coffee May Raise Heart Disease Risk
FEB 24, 2021
Drinking Lots of Unfiltered Coffee May Raise Heart Disease Risk
While there has been a lot of debate about whether or not coffee is good for you, a new study reported in Clinical Nutri ...
MAR 02, 2021
Cardiology
Creating a Light Switch in the Heart to Regulate Heart Rate
MAR 02, 2021
Creating a Light Switch in the Heart to Regulate Heart Rate
Often when it is dark, we go for a flashlight or our phone to see where we are going. What if I told you that is much th ...
JUN 30, 2021
Clinical & Molecular DX
A Deep Learning Tool for Faster, Better Heart Disease Diagnoses
JUN 30, 2021
A Deep Learning Tool for Faster, Better Heart Disease Diagnoses
A new deep learning tool could help slash the time it takes to interpret cardiology scans to diagnose obstructive corona ...
JUL 12, 2021
Cardiology
Myocarditis in Children is Usually Due to a Virus
JUL 12, 2021
Myocarditis in Children is Usually Due to a Virus
The heart is a muscle, and the wall of the heart has several layers. In a condition called myocarditis, the middle layer ...
AUG 12, 2021
Cardiology
Benefits of Plant-Based Diets Demonstrated in Long-Term Study
AUG 12, 2021
Benefits of Plant-Based Diets Demonstrated in Long-Term Study
New research has confirmed studies that have indicated how beneficial a diet rich in nutritious foods like fruits, veget ...
AUG 29, 2021
Cardiology
Bystanders Can Help Cardiac Arrest Victims Survive
AUG 29, 2021
Bystanders Can Help Cardiac Arrest Victims Survive
New research has indicated that if someone is having a heart attack, a swift response from anyone that might be nearby c ...
Loading Comments...