FEB 21, 2018 2:48 PM PST

How a Heart Attack Affects the Kidneys

WRITTEN BY: Kara Marker

The inflammatory response following a heart attack affects another organ too: the kidneys. From the University of Alabama at Birmingham, scientists investigate a bioactive compound, resolvin D1, and its ability to protect the kidneys from tissue damage following a heart attack.

A micrograph showing a type of kidney disease that is inherited, called polycystic kidney disease. Credit: Wikimedia user Nephron

In the heart, tissue damage from a heart attack stretches the left ventricle and contributes to heart failure. Heart disease and kidney disease are intricately connected, as the heart’s job is to pump blood and the kidneys’ job is to filter the blood, removing waste and extra water. The two conditions are both exacerbated by high blood pressure and diabetes.

A bioactive compound called resolvin D1 has been shown in the past to - as its name suggests - resolve the inflammatory response that naturally occurs as the body’s reaction to heart attack. Inflammation is healthy as an initial, short-lived response to heart attack. Immune cells called macrophages engulf dead and dying cells through a process called phagocytosis. But if inflammation goes on too long, it can do more harm than good in both the heart and the kidneys.

Resolvin D1, naturally produced by the immune system to prevent the inflammatory response from going overboard, can also limit the damage from kidney inflammation after heart attack. The new University of Alabama at Birmingham study highlights four specific ways resolvin D1 does it:

  1. Induces immune cells to leave the damaged heart tissue to prevent too much inflammation

  2. Expedites the macrophage transition to their reparative role instead of their phagocytic role

  3. Regulates microRNA activity, increasing the amount of regenerative micrRNAs, which control gene expression after a heart attack

  4. Reduces kidney damage by removing white blood cells

Researchers from the study tested resolvin D1 in a mice model of heart attack. Some mice were given therapeutic doses of the bioactive compound and some were not. The mice who were not given resolvin D1 experienced significant variation in microRNA activity and exhibited various signs of kidney inflammation after heart attack. Mice who did receive resolvin D1 had fewer regulatory changes in microRNA and did not show the same signs of kidney damage.

Resolvin D1 has yet to be studied in humans to confirm its ability to reduce kidney damage after a heart attack outside the context of mice. But if human studies were to validate the compound’s effectiveness, it could make a huge difference in a clinical setting for people recovering after a heart attack.

The present study was published in The FASEB Journal.

Sources: American Journal of Pathology, National Kidney Foundation, Journal of Molecular and Cellular Cardiology, University of Alabama at Birmingham

About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
JUN 25, 2020
Cardiology
Using RNA to Predict Acute Ischemic Strokes
JUN 25, 2020
Using RNA to Predict Acute Ischemic Strokes
Strokes are a leading cause of death and long term-disability across the globe. Ischemic strokes (IS) or acute ischemic ...
JUL 21, 2020
Clinical & Molecular DX
A Lab on a Chip Could Save Your Life in an Emergency
JUL 21, 2020
A Lab on a Chip Could Save Your Life in an Emergency
Picture this: a hiker on a backcountry trail falls down a rocky embankment, and is left with a deep gash on the leg afte ...
OCT 08, 2020
Cardiology
Omega-3 Enriched Chicken as a Fish Alternative for Omega-3 Fatty Acids
OCT 08, 2020
Omega-3 Enriched Chicken as a Fish Alternative for Omega-3 Fatty Acids
We have all seen those articles telling us to get more omega-3 fatty acids in our diet. Many studies point to these spec ...
OCT 13, 2020
Cardiology
A Kidney Toxin Could Act as a Biomarker for Cardiovascular Risk
OCT 13, 2020
A Kidney Toxin Could Act as a Biomarker for Cardiovascular Risk
Biomarkers have taken the diagnostic field by storm over the past decade. The search for stable, easy to access indicato ...
NOV 05, 2020
Cardiology
Investigating Platelet-Derived Extracellular Vesicles in Blood Clotting
NOV 05, 2020
Investigating Platelet-Derived Extracellular Vesicles in Blood Clotting
In our bodies, there are millions of signals and packages being sent and received every second. In the past several deca ...
NOV 10, 2020
Cardiology
Liposomal Delivery Could Help Prevent Doxorubicin Cardiotoxicity
NOV 10, 2020
Liposomal Delivery Could Help Prevent Doxorubicin Cardiotoxicity
One of the greatest failures of modern cancer therapies is the rather substantial off-target toxic effects many radio-, ...
Loading Comments...