MAY 21, 2019 6:12 PM PDT

Visualizing the Maturation of T Cells in the Thymus

WRITTEN BY: Carmen Leitch

Scientists have visualized how the body uses to tests out important defensive cells and captured the process on video.  The body uses immune T-cells to act as the first line of defense, monitoring the body for invading pathogens like viruses or bacteria. Before those cells are put to use, they must undergo a training process that has now been imaged and described in a report published in Nature Communications

Developing killer T-cells (purple and white) are tested by dendritic cells (yellow), and others, to see if they react to normal proteins from the body. / Credit: University of Texas at Austin

T-cells can also go awry, and attack the body’s own cells by mistake. That dysfunction lies at the heart of some autoimmune diseases such as type 1 diabetes, in which the insulin-producing cells of the pancreas get destroyed. This new study may offer new insights into these disorders.

"T-cells have the daunting task of recognizing and fighting off all of the diverse pathogens that we encounter throughout our lives while avoiding attacking our own healthy tissue," explained study co-author and associate professor Lauren Ehrlich. "These cells mature in the thymus, an organ just above the heart, where they 'get educated' to not attack the body."

Study co-author Jessica Lancaster, a postdoctoral researcher, and Ehrlich used a mouse thymus to take video of the maturation mechanism in action. They utilized a set of powerful lasers and fired short pulses while scanning through living tissue slices. They were able to reconstruct cell signals and movements. The researchers observed other cells in the thymus helping the T-cells to mature; the T-cells were given the chance to encounter many normal human proteins that they must ignore once they are released to scan the body for invaders. Different cell types worked together to ensure that the T-cells would be safe to unleash in the body and that if they began to fail, they would self-destruct.

The researchers are hopeful that their imaging tool will help other investigators learn more about the processes occurring in the thymus. 

Learn more about the maturation of T-cells in the thymus from the video.

Sources: AAAS/Eurekalert! via University of Texas at Austin, Nature Communications

About the Author
  • Experienced research scientist and technical expert with authorships on over 30 peer-reviewed publications, traveler to over 70 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
JUN 11, 2021
Cell & Molecular Biology
Bad Fat in the Tumor Microenvironment May Disrupt Killer T Cells
JUN 11, 2021
Bad Fat in the Tumor Microenvironment May Disrupt Killer T Cells
The immune system can detect and destroy pathogenic and cancerous cells, but sometimes those dangerous cells can evade t ...
JUN 14, 2021
Coronavirus
COVID-19 May Cause Diabetes
JUN 14, 2021
COVID-19 May Cause Diabetes
Reporting in Cell Metabolism, an international team of researchers has suggested that COVID-19 has caused diabetes in so ...
JUL 02, 2021
Genetics & Genomics
Fish Models Provide New Insight Into Rare Genetic Diseases
JUL 02, 2021
Fish Models Provide New Insight Into Rare Genetic Diseases
Fish can serve as good research models. They can develop quickly, outside of the mother where they can be observed. Some ...
JUL 11, 2021
Cell & Molecular Biology
A Taste for Sugar is Discovered in Songbirds
JUL 11, 2021
A Taste for Sugar is Discovered in Songbirds
It's been thought that songbirds are unable to taste sugar. Songbirds lack a protein that's crucial for many animals inc ...
JUL 23, 2021
Cancer
Repurposed Antibiotics Show Promise Against Skin Cancer
JUL 23, 2021
Repurposed Antibiotics Show Promise Against Skin Cancer
In experiments with mice, researchers from the Netherlands have found that some antibiotics may be effective in tre ...
JUL 29, 2021
Clinical & Molecular DX
Sewage Sleuths: Tracking COVID Variants in Wastewater
JUL 29, 2021
Sewage Sleuths: Tracking COVID Variants in Wastewater
Since the dawn of the pandemic, one of the biggest challenges has been monitoring the crowned enemy as it spread through ...
Loading Comments...