DEC 13, 2021 10:42 AM PST

The Body Can Use Fat to Fuel the Fight Against Bacterial Infection

WRITTEN BY: Carmen Leitch

A new study reported in Nature Communications has shown how the body might use fat as fuel in the battle against a Salmonella infection. According to the Centers for Disease Control and Prevention, Salmonella bacteria cause an estimated 1.35 million infections every year in the United States alone. The symptoms include vomiting, abdominal pain, or fever, and may lead to sepsis. Although most of the time, people recover within about a week on their own, the infection leads to the hospitalization of about 26,500 people and the deaths of 420 Americans every year.

Cropped from a medical illustration of drug-resistant, Salmonella serotype Typhi bacteria / Credit: Centers for Disease Control and Prevention (CDC)/  Medical Illustrator: James Archer

The bone marrow is home to hematopoietic stem cells (HSCs), which generate blood cells, including some that fight infection. A bacterial infection is known to stimulate activity in the HSCs.

In this study, the researchers found that when a Salmonella infection occurs, HSCs begin to take up free fatty acids. Those fatty acids are released by fat cells, or adipocytes, which are stimulated by signals from the bone marrow, After being powered by the fatty acids, the HSCs are free to produce plenty of white blood cells that can go fight the bacterial infection. The study also indicated that a molecule called CD36 was necessary for stem cells in there bone marrow to take up the free fatty acids.

The study authors are hopeful that this work will improve treatment options for people who are dealing with bacterial infections, particularly as more pathogenic bacteria develop resistance to common antibiotics. It may be possible to use a strategy based on this data to bolster the immune response to a bacterial infection.

"Our results provide insight into how the blood and immune system is able to respond to infection. Fighting infection takes a lot of energy and fat stores are huge energy deposits, which provide the fuel for the blood stem cells to power up the immune response," said co-corresponding study author Dr. Stuart Rushworth of the University of East Anglia's Norwich Medical School.

"Working out the mechanism through which this fuel boost works gives us new ideas on how to strengthen the bodies fight against infection in the future," added Rushworth.

Sources: University of East Anglia, Nature Communications

About the Author
BS
Experienced research scientist and technical expert with authorships on over 30 peer-reviewed publications, traveler to over 70 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
MAR 23, 2022
Cell & Molecular Biology
A New Type of Cell Death is Discovered
MAR 23, 2022
A New Type of Cell Death is Discovered
Organisms from plants to fungi to animals also need copper for normal health. Copper is involved in several basic biolog ...
APR 17, 2022
Immunology
Finding the Cause of Severe Asthma
APR 17, 2022
Finding the Cause of Severe Asthma
Asthma is a chronic inflammatory disorder in which the airways narrow, which impairs breathing and causes coughing or ti ...
APR 20, 2022
Health & Medicine
The Link between Mental Health and COVID Breakthrough Infection
APR 20, 2022
The Link between Mental Health and COVID Breakthrough Infection
Researchers from University of California San Francisco and the San Francisco Veterans Affairs Health Care System conduc ...
APR 26, 2022
Neuroscience
How Neurons Move as the Brain Forms
APR 26, 2022
How Neurons Move as the Brain Forms
If a body is going to function correctly, the cells need to be in the right place. Scientists have learned a lot about h ...
APR 28, 2022
Cancer
Can Urine Help Detect Prostate Cancer?
APR 28, 2022
Can Urine Help Detect Prostate Cancer?
It is estimated that over 250.000 men in the United States will receive prostate cancer diagnoses in 2022, acc ...
MAY 07, 2022
Neuroscience
Higher Antioxidant Levels Linked to Lower Dementia Risk
MAY 07, 2022
Higher Antioxidant Levels Linked to Lower Dementia Risk
Higher levels of antioxidants in the blood are linked to a lower risk of dementia. The corresponding study was published ...
Loading Comments...