JUL 02, 2016 07:09 AM PDT

Contagious Cancer Observed in Mollusks

WRITTEN BY: Carmen Leitch
The transmission of cancer from one animal to another is considered extremely rare. Such an event has been observed previously in only a few examples - tasmanian devils, hamsters and dogs. Scientists have now found, however, it seems to be a relatively common phenomenon among bivalves, a class of marine and freshwater mollusks. 
Left to right: 1. Mussels (Mytilus trossulus) at Copper Beach in West Vancouver, Canada 2. Cockles (Cerastoderma edule) collected in the ria of Arousa in Galicia, Spain 3. Golden carpet shell clams (Polititapes aureus) collected in the ria of Arousa in Galicia, Spain
Image 1 by Annette F. Muttray, Images 2 and 3 by David Iglesias
 
Scientists at Columbia University Medical Center (CUMC) in New York recently published a study in Nature demonstrating that a cancer called disseminated neoplasia, a leukemia-like disease affecting bivalves in many areas of the world, can spread among individuals in sea water.

After they had observed contagious cancer spreading among soft shell clams, a team that was led by Stephen Goff, the Higgins Professor of Biochemistry in the Department of Microbiology & Immunology and the Department of Biochemistry & Molecular Biophysics at CUMC, then decided to investigate whether cancers seen in other shellfish might be originating from cells that are contagious. He explains the research in the video featured below.
The investigators analyzed the DNA composition of cancerous cells and normal tissue removed from mussels (Mytilus trossulus), cockles (Cerastoderma edule), and golden carpet shell clams (Polititapes aureus) that had been collected on the coasts of Canada and Spain. They found that the DNA in the cancerous cells was genetically distinct from the host; it had been caused by independent clones coming from somewhere else. Incredibly, in the carpet shell clam the cancer DNA indicated that it had derived from an entirely different species - a case of cross-species transmission of cancer. 
A phylogenetic tree from the Nature paper showing neoplastic genotypes did not group with host tissue genotypes, consistent with transmissible cancer, instead clustering into two distinct branches, suggesting two independent cancer lineages
"Now that we have observed the spread of cancer among several marine species, our future research will investigate the mutations that are responsible for these cancer cell transmissions," said Goff. The researchers saw five lineages of cancer in the mollusks they studied.

Just in case you are wondering, there is no evidence at all that these cancers could be transmitted to a human being, and clams don’t pose any new found danger to people. Contagious cancers, at least for now, seem to be limited primarily to their species of origin.

Contagious cancers are also different from what we typically think of as cancer. They are not passed on by oncoviruses - how cancer could be considered transmissible in humans - for example, Epstein-Barr virus. In the case of shellfish, a cluster of cancer cells is passed to another animal and it propagates disease. For now, it remains to be seen if more cases like this will be uncovered.

Sources: Columbia University Medical Center, Nature, Eurekalert!/AAAS
About the Author
  • Experienced research scientist and technical expert with authorships on 28 peer-reviewed publications, traveler to over 60 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
AUG 14, 2018
Cell & Molecular Biology
AUG 14, 2018
A Totally New Look at the Cell's Powerhouse
Mitochondria don't only have their own DNA. They also have their own ribosomes....
OCT 04, 2018
Videos
OCT 04, 2018
Zebrafish as Metastatic Cancer Model
Another Koch Institute Image Award winner from 2018 is presented in this video from MIT....
OCT 11, 2018
Chemistry & Physics
OCT 11, 2018
Nobel Chemistry Prize Winners Brought Artifical Selection Into Chemistry
Last Wednesday, Oct 3rd, the Royal Swedish Academy of Sciences announced the winners of 2018 Nobel Prize in Chemistry: Frances H. Arnold, George P. Smith,...
OCT 14, 2018
Technology
OCT 14, 2018
4-D Microscope Offers Look Into Early Development
A recent developed microscope has allowed scientists to hold a front-row view on the “drama of mammalian development”. Scientists can now see i...
OCT 14, 2018
Videos
OCT 14, 2018
An Ancient Genetic Element can Help Fight Cancer
Researchers have been trying a variety of ways to boost the immune system we all have so it's able to fight off cancer....
OCT 15, 2018
Cell & Molecular Biology
OCT 15, 2018
Revealing Fat's Role in Diabetes Development
New research may change how we look at type 2 diabetes, an acquired disease....
Loading Comments...