APR 05, 2017 7:39 PM PDT

An Unprecedented Window Into a Human Cell

WRITTEN BY: Carmen Leitch

Comprehensive knowledge of the functions of a human cell is the key to understanding health and disease. The Allen Institute for Cell Science has developed a new tool called the Allen Cell Explorer, a digital view into a human cell to support biomedical research. The website has integrated data obtained from large-scale, three-dimensional imaging; it uses deep learning to make predictive models in a variety of areas like cell organization, gene edited human stem cells and other very useful applications. The Allen Institute for Cell Science aims to use the Cell Explorer to share the resources they create from a central location. The video below explains the new resource.

"Cells are incredibly complex, with thousands of moving and interacting parts that work together to drive and regulate both cell architecture and behavior," sid Rick Horwitz, Ph.D., Executive Director of the Allen Institute for Cell Science. "We are beyond excited to launch the Allen Cell Explorer website and to share our cells, incredible image data, predictive models and more with the global scientific community."

"The Allen Cell Explorer gives an extraordinary view into the organization of human cells,” commented Allan Jones, Ph.D., President and CEO of the Allen Institute. "The first installment of these freely available tools from the Allen Institute for Cell Science follows in our legacy, started with the Allen Institute for Brain Science and the Allen Brain Atlas, of creating and sharing powerful open science tools that fuel innovation around the world."

The Integrated Cell Model, is the main attraction in the Allen Cell Explorer launch, and the researchers said it’s the first model that utilizes deep learning to predict the organization of human stem cells. The scientists used thousands of excellent human stem cell images and computation to understand thr organization of cells. On the website, comparisons can be made between what is predicted by the Integrated Cell Model and actual images, and it confirms the powerful accuracy of the predictions. The developers expect future updates will enable users to compose and explore virtual cells in three dimensions.

"This is the first time researchers have used deep learning to try and understand the elusive question of how actual cells are organized," said Horwitz. "The cartoons we rely on in textbooks, which are based on an artist's interpretation of data from a relatively small number of cells, will eventually be replaced by data driven models of this kind from very large numbers of cells."

The 3D Cell Viewer is another tool that can be accessed from the portal; users can access a collection of human stem cells captured in three dimensions. Thousands of gene edited cells can be studied and manipulated, enabling the exploration of intracellular organization in all its varieties.

Allen Institute researchers have found astonishing variability of the intracellular organization inside human stem cells -- even among cells that are clones of one another. Here is a sample of 100 cells from the Allen Cell Explorer showcasing that variability. Each structure is color labeled: magenta -- DNA, cyan -- cell membrane. / Credit: Allen Institute for Cell Science

"One of the things that excites me most about the launch of the Allen Cell Explorer is how it uses cells that are far more relevant to human biology than the cultured cells that have been used by necessity for much of modern biomedical research," said Anne E. Carpenter, Ph.D., Director of the Imaging Platform at the Broad Institute of Harvard and MIT.

"Taken as a whole, this publicly available portal will enable researchers to ask important new questions about the variability of cells, and how they change as they grow, differentiate and respond to drugs," said Horwitz. "Working as a community, we can apply and expand on these tools to make leaps forward in the field of cell biology and have great impact on our study of human health and disease."

 

Sources: AAAS/Eurekalert! via Allen Institute

About the Author
  • Experienced research scientist and technical expert with authorships on over 30 peer-reviewed publications, traveler to over 70 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
SEP 15, 2020
Cancer
Soy helps post-op treatment of bone cancer
SEP 15, 2020
Soy helps post-op treatment of bone cancer
New research published in the journal Acta Biomaterialia highlights the post-operative benefits of soy in treatment ...
OCT 18, 2020
Cell & Molecular Biology
Small RNA is Connected to Bacterial Pathogenicity
OCT 18, 2020
Small RNA is Connected to Bacterial Pathogenicity
It's thought that as much as half of the global population carries a bacterium called Helicobacter pylori in their stoma ...
OCT 19, 2020
Cell & Molecular Biology
Mapping the Human Proteome
OCT 19, 2020
Mapping the Human Proteome
To learn more about biology and medicine, researchers have used advances in molecular techniques and computational biolo ...
NOV 01, 2020
Plants & Animals
Plant Hormone Auxin Helps Orient Growth of Plant Veins
NOV 01, 2020
Plant Hormone Auxin Helps Orient Growth of Plant Veins
There are veins in plants that move nutrients and other important molecules around. These veins have to be carefully org ...
NOV 12, 2020
Genetics & Genomics
Liposomes Potentially Safer Alternative to Viruses for CRISPR Delivery
NOV 12, 2020
Liposomes Potentially Safer Alternative to Viruses for CRISPR Delivery
To repair disease-causing errors in the genome, gene editing reagents like those used in CRISPR-Cas9 first have to reach ...
NOV 27, 2020
Genetics & Genomics
Gravity Affects Gene Expression
NOV 27, 2020
Gravity Affects Gene Expression
If people are going to explore deep space, we should learn more about the effects that such an environment would potenti ...
Loading Comments...