A biopsy is an invasive, interventional procedure that involves extracting a tissue sample for the diagnosis of certain diseases, such as breast cancer. It can effectively differentiate malignant cells from benign ones, which can otherwise be overlooked by other diagnostic methods like CT and MRI scans. However, the puncturing of skin and other tissues bear the risk of infections, bleeding, or even spreading cancer.
A team of researchers at Johns Hopkins University reported that they developed a nimble microscopic device that is capable of isolating and retrieving single-cell samples in vivo. Unlike all previous inventions, their "microgrippers" can "excise, capture, and manipulate" individual cells in one single process.
These single-cell grippers have four triangle-shaped digits powered by mechanical tension, derived from the chemical bonds of their silicon oxides base. To allow the microdevices to travel through narrow blood vessels under the guidance of an external magnetic field, scientists also integrated a layer of iron into the grippers. Finally, biocompatible paraffin wax was used to wrap around the grippers and provide a heat controlled trigger. The assembled devices enabled the researchers to remotely capture individual cells on-demand.
The Johns Hopkins group believes that their invention could advance the development of single-cell scale biopsy tools, and potentially make its way to other applications such as lab-on-a-chip devices, microrobotics, and minimally invasive surgery.
Their work is published in the journal Nano Letters.
Source: C&EN via Youtube