JUL 03, 2018 10:53 AM PDT

Blood Test Deciphers Your Internal Rhythm

WRITTEN BY: Kara Marker

A personalized reading of your circadian rhythm could help scientists prescribe the exact time of day that drug treatments will be the most effective. A new study from Charité - Universitätsmedizin Berlin describes how scientists use biomarkers to determine a person’s internal rhythm.

Credit: Kramer/Charité

The body’s natural 24-hour cycle is called the circadian rhythm. A person’s unique circadian rhythm is often referred to as a “chronotype.” The circadian rhythm dictates your regular pattern of going to sleep at night and waking up in the morning. Researchers from the current study developed a blood test to characterize a person’s unique chronotype, a categorization that could help doctors known the best times for administering drugs.

Identifying the time within a person’s internal rhythm that is best for taking certain drugs could minimize the risk of side effects and maximize the drug’s efficacy. Scientists refer to this therapeutic approach as “personalized chronotherapy.”

Your body’s rhythm depends on the time of the day, and the rhythm is linked to how the body functions every day. For example, some drugs work better when taken in the morning versus at night. Your internal rhythm is also connected to whether you consider yourself to be a “night person” versus a “morning person.” A 2016 Nature Communications study of almost 90,000 people found 15 gene varieties linked to a person preferring either staying up late or waking up early.

The present study’s aims included identifying biomarkers in the blood that depict a person’s unique circadian rhythm. Researchers measured and analyzed gene activity throughout one day from 20,000 genes in several study participants with the same blood type. Then, they used specialized computer algorithms to identify 12 genes that “reliably report internal time.” Based on these findings, researchers believe that the biomarkers they found in just one blood sample can tell the difference between an early bird and a night owl.

"Such a therapy taking time of day into consideration has been rarely applied until now, since a simple diagnostic was unavailable,” explained study leader Achim Kramer. “We think this novel objective test of internal time can contribute to time of day gaining more meaning in diagnosis and therapy."

Going forward, Kramer and others plan to continue their studies by investigating the potential to adapt chronotherapy to a person’s unique circadian rhythm as measured with blood biomarkers.

The present study was published in the Journal of Clinical Investigation.

Sources: Sleep, ScienceAlert, Charité - Universitätsmedizin Berlin

About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
OCT 24, 2020
Clinical & Molecular DX
Software Flags Elevated Cerebral Palsy Risk in Premies
OCT 24, 2020
Software Flags Elevated Cerebral Palsy Risk in Premies
Diagnostic imaging scientists have developed a software tool for predicting the future onset of cerebral palsy in babies ...
NOV 03, 2020
Clinical & Molecular DX
"Hello? It's Me, the Coronavirus."
NOV 03, 2020
"Hello? It's Me, the Coronavirus."
Researchers at MIT have discovered an unlikely way of discerning those with COVID-19 from healthy individuals — si ...
NOV 24, 2020
Cancer
Using Restfulness as a Metric for Measuring Sleep Quality and Cardiovascular Risk
NOV 24, 2020
Using Restfulness as a Metric for Measuring Sleep Quality and Cardiovascular Risk
Did you know sleeping is great? Apparently, getting a full eight hours every night can make you look fabulous and solve ...
DEC 24, 2020
Clinical & Molecular DX
Feeling Unmotivated? It Could Be Dementia.
DEC 24, 2020
Feeling Unmotivated? It Could Be Dementia.
Apathy, characterized by a pronounced lack of enthusiasm, motivation, or interest, is a predictor of the future onset of ...
JAN 18, 2021
Cancer
An "E-Nose" Could Help Doctors Diagnose Breast Cancer and Its Subtypes
JAN 18, 2021
An "E-Nose" Could Help Doctors Diagnose Breast Cancer and Its Subtypes
Breast cancer is one of the most well-studied cancers in modern medicine. Diagnostics can already differentiate between ...
JAN 26, 2021
Clinical & Molecular DX
Prostate Cancer Screening: No More False Positives
JAN 26, 2021
Prostate Cancer Screening: No More False Positives
A new diagnostic test powered by artificial intelligence has been found to detect prostate cancer markers in urine sampl ...
Loading Comments...