DEC 26, 2015 05:19 AM PST

Nanotech Weapon Against Hospital Acquired Infections

WRITTEN BY: Xuan Pham
Bacterial biofilms are among the biggest scourges in hospitals, causing infections that are difficult to treat because most are antibiotic resistant. However, scientists found that heating up a specialized form of nanoparticles can weaken the biofilm and make them easier to kill.
 
Bacterial biofilm on a indwelling catheter

Microbial organisms are everywhere. We rarely take notice of these things in our daily lives; however they have a big presence in the hospital setting. In its planktonic form, the bacteria grow as single, independent cells, causing acute infections that can be treated with antibiotics. In its biofilm form, the bacteria exist as aggregated colonies that secrete a slimy film, which serves to protect them against the environment.
 
More than 80% of infections are attributed to biofilms. In addition to growing on medical devices like dialysis catheters and contact lenses, biofilms can also dwell inside patients -- in the respiratory, gastrointestinal and urinary tracts, oral cavities, eyes, ears, wounds, heart and cervix. Because the slime protects them against antibiotics, some infections by biofilms are resistant to drugs and develop into a chronic state.

Bacteria in biofilms multiply by dispersing individual cells from the colony. As in the planktonic state, these single cells are much less protected and more vulnerable to drug treatments. Exploiting this biological weakness, researchers at the University New South Wales in Australia found a way to trick the biofilm to disperse into single cells more frequently.
 
Lead by Drs. Cyrille Boyer and Nicolas Barraud, the scientists treated the biofilm with iron oxide nanoparticles and then heated it with a magnetic field. By raising the temperature by at least 5 degrees Celsius, the team found that the biofilm easily shed into single colonies. A polymer coating on the iron oxide nanoparticles facilitated and maintained this dispersed state.
 
Using the opportunistic human pathogen Pseudomonas aeruginosa as a model organism, Boyer’s team found that the antibiotic gentamicin killed more bacteria treated with the heated nanoparticles.

Once dispersed, the bacteria are easier to deal with, creating the potential to remove recalcitrant, antimicrobial-tolerant biofilm infections. – Dr. Boyer

The study has huge positive implications for the clinical setting where biofilm infections are rising. If this polymer-coated iron oxide nanoparticle technology can be implemented in hospitals it could dramatically decrease hospital-acquired infections.

Here's another way that scientists are tackling the bacterial biofilms:
 

Sources: Nature Open Reports, UNSW Press release
About the Author
  • I am a human geneticist, passionate about telling stories to make science more engaging and approachable. Find more of my writing at the Hopkins BioMedical Odyssey blog and at TheGeneTwist.com.
You May Also Like
JUN 05, 2018
Clinical & Molecular DX
JUN 05, 2018
"ImmunoPET" Imaging Identifies IBD Inflammation
Scientists are now applying PET imaging to detect inflammation in people with inflammatory bowel disease (IBD). This could help countless IBD patients conn...
JUL 05, 2018
Cardiology
JUL 05, 2018
Stem Cell Treatment Restores Failing Macaque Monkey Hearts
A new way to prevent heart attack from turning into heart failure relies on heart cells made from human embryonic stem cells. For now, researchers are test...
JUL 19, 2018
Microbiology
JUL 19, 2018
Mom's Microbiome has a Big Impact on Kid's Autism Risk
For many years, scientists have been trying to learn more about the causes of autism....
NOV 21, 2018
Cardiology
NOV 21, 2018
What We Know About Kawasaki Disease
Kawasaki disease discovered by Dr. Tomisaku Kawasaki, a Japanese pediatrician, is a rare type of vasculitis, or inflammation of the blood vessels. It&rsquo...
NOV 26, 2018
Health & Medicine
NOV 26, 2018
The Role of Clinical Lab Scientists
The clinical laboratory is the heart of any hospital or healthcare system. It is responsible for greater than 70% of medical diagnoses and decisions made b...
NOV 29, 2018
Genetics & Genomics
NOV 29, 2018
Pet Genomics Might Need to be Leashed
Experts say genetic testing for pets is not quite ready for the market, but that hasn't stopped companies from selling tests....
Loading Comments...