MAY 28, 2016 6:53 AM PDT

First Simultaneous Skull-Scalp, Kidney, and Pancreas Transplant

WRITTEN BY: Xuan Pham
In a medical first, doctors from Houston, Texas reported a simultaneous scalp, skull, kidney, and pancreas transplant from one donor to a recipient. The drastic, never-been-done-before procedure allowed a patient to reclaim better health outcomes that would otherwise not be possible. Additionally, doctors hope this medical case will open the door for more combined transplants in the future.
 
Texas man gets new skull-scalp transplant along with 2 organs
The recipient of this landmark procedure is a 55-year-old man who has type 1 diabetes. The patient underwent kidney and pancreas transplantation over 20 years ago, but the kidney organ is now failing. In 2005, the patient developed an aggressive cancer on his scalp that was successfully treated, but left him with a large, non-healing scalp wound that was prone to severe infections.
 
His team of doctors weighed their options to treat the multi-organ complications in this patient. They concluded that a scalp and skull transplant could be performed at the same time the kidney and pancreas transplant was taking place, provided the organs came from the same donor.
 
The scalp and skull transplantation is different than the solid organ transplant in that it involves connecting multiple types of tissues, like skin, muscle, blood vessels, nerves, and bone. Known as vascularized composite allotransplantation, or VCA, the procedure requires a lifelong need for immunosuppressive therapy to prevent rejection. Previous face and hand transplants proved the success of VCA, but doctors have not attempted to combine VCA with other organ transplants at the same time.
 
In the case of this diabetic patient who was already taking immunosuppressive medications, the scalp/skull VCA combined with the double organ transplant seemed a to be a viable measure to both the doctors and the patient.
 
It took 18 months to find a suitable deceased donor who matched the patient’s immune type, head size, skin color, and hair pattern. Then it took 20 surgeons 15 hours in the operating room to make the transplant a success.
 
Doctors noted the transplants received adequate blood supply and seemed to function normally. The patient experienced a brief episode of rejection with the scalp/skull transplant that was successfully thwarted. A year later, the patient is reported to be in good health, benefiting from his transplanted organs and the corrected defect on his skull.
 
 
"Hopefully, this case and others like it will help to widen the narrow indications for this fascinating new field of reconstructive surgery," said Jesse Creed Selber at the University of Texas M.D. Anderson Cancer Center, first author of the report.

Additional source: EurekAlert!, Plastics and Reconstructive Surgery Journal
About the Author
  • I am a human geneticist, passionate about telling stories to make science more engaging and approachable. Find more of my writing at the Hopkins BioMedical Odyssey blog and at TheGeneTwist.com.
You May Also Like
FEB 15, 2020
Clinical & Molecular DX
FEB 15, 2020
FDA nod for AI-powered technology to detect strokes
The US Food and Drug Administration (FDA) has provided clearance for a novel technology that uses artificial intelligenc ...
MAR 12, 2020
Clinical & Molecular DX
MAR 12, 2020
Molecular biomarker in saliva predicts childhood obesity
Epigenetic changes modify how genes are switched on and off, without altering DNA’s genetic code sequence. These e ...
MAR 23, 2020
Microbiology
MAR 23, 2020
The Loss of a Sense of Smell May be a Major Symptom of COVID-19
The loss of the sense of smell may be a symptom of a COVID-19 infection in people with no other symptoms.
APR 04, 2020
Clinical & Molecular DX
APR 04, 2020
AI Finds New Predictive Markers of Covid-19 Severity
Researchers and healthcare organizations are putting their heads together to consider how technology could ease the ever ...
APR 23, 2020
Immunology
APR 23, 2020
COVID "Immunity Passports" Are a No-Go
  Authorities are caught between dealing with the competing urgencies of abating the COVID-19 health crisis and the ...
APR 29, 2020
Clinical & Molecular DX
APR 29, 2020
Saliva is Preferable to Deep Nasal Swabs for COVID-19 Testing
The coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Incre ...
Loading Comments...