JUL 08, 2016 06:17 AM PDT

'Good Vibrations' Turn Stem Cells into Bone Cells

WRITTEN BY: Xuan Pham
Earlier this year, scientists made history when they discovered evidence of gravitational waves. Now researchers in the United Kingdom say the same technology that detected the atomic ripples in our space can be used to turn stem cells into bones in the lab.

Nanoscale vibrations kickstart stem cells into bone cells | Image: ostinol.com 

Bones are complicated tissues in our bodies. They vary in size and shape, and even density. Thus when patients are stricken with diseases, like congenital deformities, or damage their bones by accidents, it can be exceedingly challenging for doctors to find and ‘install’ replacement parts. Even so, bone transplants are the second most common transplanted tissues, next to blood. Thus, finding alternatives to donor bone tissues is of great interest.
 
Researchers at the University of the West of Scotland (UWS) and the University of Glasgow (UG) began by observing that bones normally need some sort of physical stimulation to thrive. Just as our muscles can weaken and die from disuse, bones can erode without pressure or movement. This problem is most apparent for astronauts whose bones are weaker and more brittle from the weightlessness in space.
 
Normal movements and pressure keep bones healthy and growing – a process known as ‘bone loading.’ Thus, the team wondered whether they could stimulate stem cells with vibrations to induce the cells to turn into bone cells. Stem cells are undifferentiated progenitor cells that have the capacity to develop into many different types of tissues.
 
Indeed, the team used high frequency vibrations, called ‘nanokicking,’ to simulate bone loading. The technique turned the stem cells into bone producing cells, which can be transplanted into a site to fuse and heal the damaged bones.
 

 "The bioreactor we have designed brings together fields of research from different ends of the spectrum: stem cell research on the building blocks of our bodies, to technology used to detect the ripples in space and time caused by the collisions of massive objects. It's amazing that technology developed to look for gravitational waves has a down-to-earth application in revolutionizing bone treatments for cleaner, safer and more effective therapy,” said Matt Dalby, professor at the University of Glasgow.
 
This method of bone transplant is different than conventional methods of transplanting a bone graft, organic or artificially produced, to the recipient. Rather than a structured piece of tissues, this technique relies on cells to fuse or heal a bone wound. But it’s also reasonable to think that the newly derived bone cells could also grow on a scaffold, which can then be transplanted into a patient who may require more extensive bone reconstruction.
 
There are other benefits to transplanting bone cells. First, this technique bypasses the need for expensive and potentially harmful drugs and growth factors commonly used to induce bone growth in the lab. Second, because the stem cells can come from the patient, the subsequent transplants won’t cause rejection as is common with donor tissues. And of course, regrowing bones with a patient’s own cells relieves the burden of finding compatible donors, and eliminates the need for painful harvesting procedures.
 
The team has their eyes on the prize: They hope lab-grown bone cells can be tested in human clinical trials within 3 years, and the therapy can be available to all patients within 10 years. Ultimately, they are looking to sidestep the transplant altogether and directly stimulate the patient’s fractures to heal without surgery.

Curious about gravitational waves? Here's an explanation:

Additional source: MNT
About the Author
  • I am a human geneticist, passionate about telling stories to make science more engaging and approachable. Find more of my writing at the Hopkins BioMedical Odyssey blog and at TheGeneTwist.com.
You May Also Like
JUN 02, 2018
Immunology
JUN 02, 2018
New Test Predicts Lupus Onset
Based on several different factors, scientists have a new risk index for predicting who will develop lupus. From the Feinstein Institute for Medical Resear...
JUL 01, 2018
Videos
JUL 01, 2018
Growing Patient Cells on a Chip for Personalized Drug Screens
This work could help eliminate animal models, and tailor medicine to the patient....
NOV 01, 2018
Cell & Molecular Biology
NOV 01, 2018
Researchers Link Parkinson's Disease and the Appendix
When a person's appendix is removed early in life, it reduces their chances of getting Parkinson's disease....
NOV 26, 2018
Health & Medicine
NOV 26, 2018
A New Test for Fibromyalgia
Anyone who has experienced severe, chronic pain knows the long process it takes to get a correct diagnosis. Many people see an average of 5-6 specialists b...
NOV 30, 2018
Immunology
NOV 30, 2018
Aspirin May Impove MS Symptoms
The medical benefits of aspirin have been known since ancient times. Hippocrates, c. 400 BC, prescribed the salicylate-rich bark and leaves of the willow t...
DEC 04, 2018
Immunology
DEC 04, 2018
Natural HIV Resistance
A team of scientists discover unique immune reactions to the one percent of HIV infected patients that are able to fend off viral propagation without antiretroviral therapy...
Loading Comments...