AUG 30, 2016 07:07 AM PDT

Coma Patient's Brain 'Jump-Started' Using Ultrasound

WRITTEN BY: Xuan Pham
A 25-year-old comatose patient is reportedly on the track to conscious recovery after an experimental ultrasound procedure appeared to have “jump-started” his brain. Doctors are still working out the details of what exactly happened, but it appears the brain stimulation spurred the man’s recovery. This is the first time such a technique and result has been documented, and it could mean new hope for coma patients.
 
A coma is medically defined as a state of deep unconsciousness from which patients can’t be awakened by normal stimuli. This can last days, months, to even years. The record for the longest-ever coma belongs to Elaine Esposito, who stayed unconscious for 37 years and 111 days.
 
Most treatment given to comatose patients are to maintain the body’s physical health. However, some experimental techniques exist to “awaken” the brain. Deep brain stimulation (DBS) is among one of the more prominent neurological technique to spur coma recovery. But, the technique is still considered highly experimental, as results are too variable to outweigh the risks of implanting electrodes deep in the brain.
 
Inspired by DBS, researchers at the University of California-Los Angeles attempted to wake the brain through non-invasive ultrasound techniques. They used a device that’s the size of a coffee cup saucer that’s capable of producing small ultrasound waves. Known as low-intensity focused ultrasound pulsation, the device was aimed at specific regions of the brain with the goal to excite neuronal tissues.
 
Indeed, the research team called their experimental technique “remarkable,” as it appeared to spur the recovery of patient suffering from a coma following a car accident. Prior to the ultrasound intervention, the patient was considered minimally conscious. By 3 days after treatment, doctors deemed the patient to have full consciousness and language comprehension. He even reportedly gave doctors a fist-bump.
 
"It's almost as if we were jump-starting the neurons back into function,” said Martin Monti, UCLA professor and lead author of the clinical study. “Until now, the only way to achieve this was a risky surgical procedure known as deep brain stimulation, in which electrodes are implanted directly inside the thalamus," he said. "Our approach directly targets the thalamus but is noninvasive."
 

While Monti and his team are highly encouraged by their patient’s outcome, they are the first to admit it could have been a coincidence. "It is possible that we were just very lucky and happened to have stimulated the patient just as he was spontaneously recovering," Monti said. Another point to note is that the patient was treated with the ultrasound 19 days after his injury. It is probable that the promising results may not hold for other patients whose injuries are more severe or have been in a coma for longer.
 
Indeed, it will be possible to know whether ultrasound can awaken the brain with more cases. The team plans to enroll more participants this fall at the Ronald Reagan Medical Center (RRMC) at UCLA.
 
 Additional sources: UCLA press release via EurekAlert!
About the Author
  • I am a human geneticist, passionate about telling stories to make science more engaging and approachable. Find more of my writing at the Hopkins BioMedical Odyssey blog and at TheGeneTwist.com.
You May Also Like
SEP 24, 2018
Genetics & Genomics
SEP 24, 2018
Towards a Blood Test for Drowsy Driving
Driving is an everyday activity for many people around the world, and it comes with serious risks....
OCT 29, 2018
Cannabis Sciences
OCT 29, 2018
Can Marijuana be Toxic?
Many users of marijuana believe that it is relatively safe, particularly because, as believed, one cannot overdose on the drug. ...
OCT 29, 2018
Immunology
OCT 29, 2018
Escape of the Tumor Cell
Tumor cells in breast cancer have proven to evade the immune responses utilizing actin cytoskeleton...
NOV 26, 2018
Health & Medicine
NOV 26, 2018
The Role of Clinical Lab Scientists
The clinical laboratory is the heart of any hospital or healthcare system. It is responsible for greater than 70% of medical diagnoses and decisions made b...
DEC 08, 2018
Cardiology
DEC 08, 2018
Atrial Fibrillation, Explained
Atrial fibrillation (A-Fib) is a term you've likely heard before. You may have even been told you live with A-Fib. What exactly is this common type of...
JAN 01, 2019
Cardiology
JAN 01, 2019
Bringing Cardiovascular Care to Rural Communities
We all know that timely access to healthcare is fundamental to good health. Still, rural residents at home and abroad face a multitude of barriers. Today,...
Loading Comments...