SEP 21, 2016 08:45 AM PDT

Metabolic Profiling of Saliva Can Predict Asthma Risks


Tests that aim to diagnose asthma in young children can often be highly stressful to both the child and the parents. Furthermore, the distress is compounded by the large margin of inaccuracy with the current available methods, most of which are not well suited for small children. Now, patients could be on the road to a much less invasive and stressful asthma test that would only involve a spit sample. The test may also have the potential to diagnose the severity and prognosis of the disease – information that could guide treatment plants for the tiny patients.

New saliva test could mean more accurate asthma diagnoses for babies. \\ Image:

In the U.S. alone, nearly 24 million Americans suffer from asthma. Of these, about a quarter (6.3 million) are children. Asthma is characterized by difficulty breathing, coughing, wheezing, and shortness of breath. The symptoms are usually brought on by certain allergens, such as tobacco smoke or dust, which irritate the airways.
With today’s medical innovations, patients with asthma learn how to prevent or manage their symptoms. Patients often carry inhalers (bronchodilators) that can provide quick short-term relief by relieving the swollen airways. Other treatments include anti-inflammatory drugs, such as inhaled corticosteroids, which work by dampening the body’s immune response to allergen triggers.
However, before patients can be treated for asthma, they must be appropriately diagnosed. Current tests include measuring the lung’s air capacity, or testing the body’s blood and urine for asthma biomarkers. While these methods may be amenable for most adults, it’s not so easy for young children and old people.

As such, a team from Loughborough University and Nottingham City Hospital in the United Kingdom asked whether asthma biomarkers may be reliably found in patient’s saliva. They used liquid chromatography-mass spectrometry to analyze saliva samples from asthma patients and compared that to healthy controls.
Indeed, saliva samples appear to show a unique metabolic profile for asthma patients. "Ten discriminant features were identified that distinguished between moderate asthma and healthy control samples with an overall recognition ability of 80 percent during training of the model and 97 percent for model cross-validation," the team wrote.
"Unlike other sampling methods, such as expired breath analysis, saliva can be collected by passive drool from the very young to the very old without causing distress,” said Colin Creaser, senior author of the study.
This means a simple cheek swab could provide all the information to diagnose asthma in even babies. Furthermore, the team noted the metabolic profile of the biomarkers could reveal the severity the disease and its progression. These valuable information could help doctors customize treatment plans for each asthma patient, making it more likely that they will have good outcomes. Of note, these results, promising as they may be for now, have to be repeated many more times in clinical trials.

Additional source: Loughborough University, CDC

About the Author
  • I am a human geneticist, passionate about telling stories to make science more engaging and approachable. Find more of my writing at the Hopkins BioMedical Odyssey blog and at
You May Also Like
MAY 21, 2018
Genetics & Genomics
MAY 21, 2018
Using CRISPR for High-throughout Genetic Assessment
Researchers can now move beyond the painstaking manipulation of individual genes....
JUL 19, 2018
JUL 19, 2018
Mom's Microbiome has a Big Impact on Kid's Autism Risk
For many years, scientists have been trying to learn more about the causes of autism....
JUL 20, 2018
Chemistry & Physics
JUL 20, 2018
X-ray Images to Get Colors
In the near future, the X-ray images from your doctor's office will no longer be just black and white, at least that's what MARS Bioimaging Ltd, an...
AUG 06, 2018
AUG 06, 2018
What's in your blood?
Even though we only tend to focus on four key blood types, there are actually hundreds of iterations of different proteins and other components that make u...
AUG 16, 2018
Clinical & Molecular DX
AUG 16, 2018
Nanotech patch makes light-up medical tests 100x brighter
Researchers have developed a high-tech fix that uses metal nanostructures to increase the fluorescence intensity by 100 times in diagnostic tests. It&rsquo...
SEP 24, 2018
Genetics & Genomics
SEP 24, 2018
Towards a Blood Test for Drowsy Driving
Driving is an everyday activity for many people around the world, and it comes with serious risks....
Loading Comments...