DEC 02, 2016 2:35 PM PST

Legal Ecstasy May Become the New PTSD Drug

WRITTEN BY: Xuan Pham
Post-traumatic stress disorder (PTSD) affects millions of people, but the disorder is notoriously difficult to treat. Even with our best treatment efforts, researchers say a significant portion of patients are still left behind.
 
But recently, the psychedelic MDMA, otherwise known colloquially as “ecstasy,” is gaining traction as an unconventional but effective treatment for PTSD. Furthermore, the FDA also saw the potential in this drug, and has approved it in a large-scale clinical trial for PTSD. The move could pave the way for legally prescribed “ecstasy” as a psychotherapy agent in the future.
 
Known on the street as “E,” “Molly,” and “millennial aspirin,” MDMA (3,4-Methylenedioxymethamphetamine) is a popular recreational psychedelic drug. The compound acts on the amygdala to induce feelings of euphoria, empathy, and otherwise heightened emotions.
 
Heavy abuse of the drug – leading to addiction, memory issues, paranoia, and other adverse symptoms – led the FDA to classify it as a Schedule 1 substance and its eventual ban. However, many researchers saw potential in MDMA as a psychotherapy drug, precisely because of how it affects the brain.
 

In a few early stage clinical trial of MDMA, patients reported working through their trauma in ways that could not be replicated with conventional treatments. One study found a 56 percent decrease in the severity of their PTSD symptoms with the use of MDMA. This shift led more than two-thirds of the patients to free themselves from the diagnosis of PTSD – a remarkable outcome considering the ineffectiveness rate of current therapies. Furthermore, the results seem to have a lasting effect, even after the drug was discontinued.
 
“The body of evidence that shows MDMA works is so strong and so encouraging,” said Rick Doblin, the founder and executive director of Multidisciplinary Association for Psychedelic Studies (MAPS), which is sponsoring the current Phase III clinical trial, involving over 200 participants.
 

In addition to obtaining the unprecedented OK from the FDA to use MDMA in the clinical trial, the team also applied for the “breakthrough therapy” status. This designation is typically reserved for drugs that can “treat a serious or life threatening disease or condition.” If granted and trial results prove promising, MDMA can be on the fast track for approval as a PTSD psychotherapy drug by as early as 2021.
 
Of note, researchers underscore that the trial is to expand the psychedelic’s medicinal uses, not its recreational potential. So to people who doubt the safety of legal ecstasy, Doblin says: “This is never going to be a take-home drug. It’ll only be prescribed by doctors with special training, for people with specific conditions.”

Additional sources: NY Times, Popular Science
About the Author
  • I am a human geneticist, passionate about telling stories to make science more engaging and approachable. Find more of my writing at the Hopkins BioMedical Odyssey blog and at TheGeneTwist.com.
You May Also Like
MAY 09, 2021
Genetics & Genomics
Another Neurodevelopmental Disorder is Discovered
MAY 09, 2021
Another Neurodevelopmental Disorder is Discovered
Researchers are identifying more rare disorders because of advances in genetic sequencing technologies, which have made ...
MAY 18, 2021
Clinical & Molecular DX
A Crystal Ball for Predicting Labor Day
MAY 18, 2021
A Crystal Ball for Predicting Labor Day
Expectant mothers may no longer have to be caught off guard—researchers have identified biomarkers in the blood th ...
MAY 15, 2021
Neuroscience
Eye Scans May Indicate Early Signs of Alzheimer's
MAY 15, 2021
Eye Scans May Indicate Early Signs of Alzheimer's
Researchers from the University of California San Francisco have found that retinal scans can detect changes in blood ve ...
AUG 08, 2021
Cardiology
Strong Links Between PTSD and Heart Disease
AUG 08, 2021
Strong Links Between PTSD and Heart Disease
The link between heart disease and stress is well known, but researchers still have a lot to learn about that associatio ...
AUG 09, 2021
Genetics & Genomics
Middle Eastern Data Fills in Some Knowledge Gaps on Human Genetics
AUG 09, 2021
Middle Eastern Data Fills in Some Knowledge Gaps on Human Genetics
Although the human genome has basically the same genes from one person to the next, there is a huge amount of variation ...
AUG 24, 2021
Clinical & Molecular DX
A New Chapter in Metastatic Breast Cancer Biomarkers
AUG 24, 2021
A New Chapter in Metastatic Breast Cancer Biomarkers
For patients diagnosed with metastatic breast cancer, it’s often not the primary tumor that has fatal consequences ...
Loading Comments...