JAN 12, 2017 6:41 AM PST

What Your Blood Says About Your Age

WRITTEN BY: Xuan Pham

Forget counting years and birthdays. Researchers find that to accurately know how old you are biologically, look no further than the biomarkers in your blood.

For years, we’ve been taught to put more emphasis on our chronological age. Doctors and health experts make recommendations for foods, drugs, activities based on chronological age since birth. For example, parents are told not to feed their baby cow’s milk until 12 months of age; in some states, booster seats are required for children 8 years or younger. The list of health rules based on our age continues. But perhaps chronological age isn’t the only way to tell how old your body is. Furthermore, it may not be the most accurate way to understand aging.

To study molecular aging and discover biomarkers that can reveal a body’s age, researchers at the Boston University School of Medicine collected blood from over 4,700 people over an 8-year study. From these samples the team analyzed 19 biomarkers, which are small chemicals in the blood. These biomarkers were involved in a host of bodily functions, including immune system processes, kidney function, and lipid metabolism.  After the biomarker signatures were compiled, the team compared these to the occurrence of diseases and the participants’ health.

Analysis revealed 26 biomarker signatures, with “signature 1” deemed as the reference point. By comparison, “signature 2 was associated with significantly lower mortality, morbidity, and better physical function,” the team wrote in their report. Another 9 signatures were associated with “higher risks for frailty, morbidity, and mortality.”

"These signatures depict differences in how people age, and they show promise in predicting healthy aging, changes in cognitive and physical function, survival and age-related diseases such as heart disease, stroke, type 2 diabetes and cancer," the team concluded in their study.

The molecular profiles have big potentials, according to the researchers. For instance, they imagine that the signatures could be used to predict how patients will respond to drugs. In this way, drug trials may build in different screening criteria to select the appropriate patients for the trials.

Better still, the molecular signatures could give a glimpse into the patient’s medical future and their predisposition for age-related conditions. This combined with genetic sequencing could provide physicians with an unprecedented dearth of information from which to guide their treatment plans for patients.

"We can now detect and measure thousands of biomarkers from a small amount of blood, with the idea of eventually being able to predict who is at risk of a wide range of diseases, long before any clinical signs become apparent," said Thomas Perls, the study’s senior author.

As promising as the results are, they still need to be replicated and further validated before hard conclusions can be drawn. Nevertheless, the results open an additional avenue, besides genetic sequencing, from which we can learn about our health predispositions.

Additional sources: Live Science

About the Author
  • I am a human geneticist, passionate about telling stories to make science more engaging and approachable. Find more of my writing at the Hopkins BioMedical Odyssey blog and at TheGeneTwist.com.
You May Also Like
APR 21, 2021
Clinical & Molecular DX
Miniature Implant Checks Oxygen Levels in Internal Organs
APR 21, 2021
Miniature Implant Checks Oxygen Levels in Internal Organs
  Berkeley researchers have created the next generation of deep tissue oxygen sensors: A tiny, wireless device that ...
JUN 01, 2021
Genetics & Genomics
Sequencing and Identifying SARS-CoV-2 Variants Efficiently
JUN 01, 2021
Sequencing and Identifying SARS-CoV-2 Variants Efficiently
  Viral surveillance can give researchers vital information about virus origins, transmission routes, affected popu ...
JUN 04, 2021
Cannabis Sciences
Neurotechnology and Saliva Tests Detect Psychoactive Effects of Cannabis
JUN 04, 2021
Neurotechnology and Saliva Tests Detect Psychoactive Effects of Cannabis
Researchers from contract research organization, KGK Science, working on behalf of neurotechnology firm Zentrela, have f ...
JUL 06, 2021
Clinical & Molecular DX
Undiagnosed Dementia Much More Prevalent Than Previously Thought
JUL 06, 2021
Undiagnosed Dementia Much More Prevalent Than Previously Thought
An analysis of data from the Health and Retirement Study has yielded a startling revelation: 91 percent of people experi ...
JUL 21, 2021
Microbiology
What Causes False Positives? Understanding Blood Culture Contamination
JUL 21, 2021
What Causes False Positives? Understanding Blood Culture Contamination
Blood culture is the most widely used diagnostic tool for the detection of bacteremia and fungemia. It is the most impor ...
AUG 17, 2021
Clinical & Molecular DX
Sleep Apnea Doubles the Risk of Sudden Death
AUG 17, 2021
Sleep Apnea Doubles the Risk of Sudden Death
Obstructive sleep apnea, or OSA, is the most commonly reported sleep disorder, with loud snoring being one of the tell-t ...
Loading Comments...