APR 08, 2017 10:19 AM PDT

Is Diabetes Reversal Within Reach?

WRITTEN BY: Xuan Pham

While treatments for diabetes management have gotten better over the year, wouldn’t it be best if we could reverse the disease altogether? The first promise of such a drug was announced recently, with a compound that seemingly normalized insulin signaling in mice.

Currently, type 2 diabetes affects more than 29 million Americans alone. And this number is predicted to increase globally. For patients with diabetes, managing their blood sugar levels requires constant care and vigilance. For the healthcare system, diabetes represents a significant financial burden. The American Diabetes Association estimates that for every $3 Medicare dollars, $1 is spent caring for people with diabetes. The burden of diabetes and pre-diabetes treatment cost America $322 billion every year.

So, it’s not just a matter of making diabetes more manageable. The most cost-efficient solution is to either prevent or reverse diabetes.

Towards that end, researchers at the UC San Diego School of Medicine focused on a drug that could restore the body’s insulin sensitivity. The pill they came up with inhibits an enzyme known as low molecular weight protein tyrosine phosphatase (LMPTP). “We found that LMPTP is a critical promoter of insulin resistance that develops during obesity,” said Stephanie Stanford, the study’s lead author.

Stopping the enzyme in the liver seemed to stop animals from developing diabetes even when exposed to a high-fat diet. “Our inhibitor increased activation of the insulin receptor in the liver, and reversed diabetes without any apparent negative side effects,” says Stanford. The liver is the organ that mainly absorbs excess sugar from the blood in the presence of insulin.

“This could lead to a new therapeutic strategy for treating type 2 diabetes,” said Stanford. If this new drug works in humans, it could be used to reverse insulin resistance, and reduce the number of people dependent on insulin shots. Thus, the next hurdle for this proof-of-concept study is a clinical trial to observe the drug’s effects in patients.

“Our compound is very specific for the target, and we do not see any side effects after treatment in mice for a month, but the next step is to rigorously establish if it’s safe for use in clinical trials,” said Stanford.

Additional source: New Scientist

About the Author
  • I am a human geneticist, passionate about telling stories to make science more engaging and approachable. Find more of my writing at the Hopkins BioMedical Odyssey blog and at TheGeneTwist.com.
You May Also Like
NOV 11, 2020
Clinical & Molecular DX
Smart Mask Detects COVID Infections, Sends Alert to Phone
NOV 11, 2020
Smart Mask Detects COVID Infections, Sends Alert to Phone
  This week, the Centers for Disease Control and Prevention issued new guidance to put the “mask debate&rdquo ...
DEC 02, 2020
Cancer
Investigating the Active Components of an Herbal Mushroom
DEC 02, 2020
Investigating the Active Components of an Herbal Mushroom
When people think of traditional medicine, often what comes to mind are the old herbal medical practices in Asian countr ...
DEC 22, 2020
Cardiology
A New 3D Imaging Method for Atherosclerosis Analysis in Mice
DEC 22, 2020
A New 3D Imaging Method for Atherosclerosis Analysis in Mice
Imaging in research may not sound glamorous, but how else would news stories get those cool looking science photos for t ...
JAN 12, 2021
Clinical & Molecular DX
Portable Sequencer Ensures All the Cancer Cells Are Gone
JAN 12, 2021
Portable Sequencer Ensures All the Cancer Cells Are Gone
Surgeons remove a tumor from the abdominal cavity of a patient. But how can they be certain that all the cancer cells we ...
JAN 18, 2021
Cancer
An "E-Nose" Could Help Doctors Diagnose Breast Cancer and Its Subtypes
JAN 18, 2021
An "E-Nose" Could Help Doctors Diagnose Breast Cancer and Its Subtypes
Breast cancer is one of the most well-studied cancers in modern medicine. Diagnostics can already differentiate between ...
FEB 09, 2021
Clinical & Molecular DX
Make Tissues Transparent to Spot Hidden Tumors, Let Machines Do the Rest
FEB 09, 2021
Make Tissues Transparent to Spot Hidden Tumors, Let Machines Do the Rest
A clearly defined border differentiates benign tumors from malignant ones. Malignant tumors start to get fuzzy around th ...
Loading Comments...