AUG 28, 2017 2:54 PM PDT

Device Helps Parkinson's Patients Better Control Tremors

WRITTEN BY: Xuan Pham

Image credit: Pixabay.com

To help Parkinson’s patients who suffer from uncontrollable tremors, London scientists have developed a device that can let doctors know precisely where to inject drugs to calm the shaking. The team said the device makes drug injections more effective, as the treatment is individualized for each patient.

Neurological diseases, such as Parkinson’s and essential tremor, are characterized by involuntary and rhythmic shaking. Most notably, the disease affects muscle movements in the hands, causing trembling and tremors as patients perform ordinary tasks like picking up a cup or writing.
 
There are no cures for these diseases yet; however, one type of therapy that can help curb the shaking involves injecting the nerves with botulinum toxin type A (BoNT-A), which is similar to Botox. This focal therapy is designed to relax or deaden the nerves that cause the shaking, thereby relieving some symptoms of the disease. But as is, this therapy provides only modest benefits to some patients.
 
“Very few clinicians inject for tremor because before now, it just didn’t work. The injections would only cause weakness,” said Mandar Jog, a scientist at Lawson Health Research Institute, and senior study author. “We realize now that was because they didn’t know where to inject.”
 
To solve this problem, Jog and his team devised a technology that they call TremorTek. Using a combination of movement sensors and computer software, the device pinpoints the exact muscles causing a patient’s tremors. That knowledge then informs the doctors where they should inject the Botox-like drugs.
 

 
“The uniqueness of our development is the simplicity of it. It records from multiple joints in a straightforward way,” said Jog. In a small clinical trial of 24 patients with essential tremor and 28 patients with Parkinson’s disease, the team demonstrated “quite significant efficacy” in combining TremorTek with the drug injections. Over the course of 38 weeks, the patients reported reduced tremors and improved quality of life, as measured by eating, drinking, and working performance.
 
For 39-year old Michael Dietrich who was diagnosed with Parkinson’s disease 7 years ago, the trial, like the disease, is “life-altering.” “Being involved in the trial [I] can do most functions that I used to do. I have seen a marked difference,” he said.
 
The team credits the marked patient response to the TremorTek’s ability to individualize the injection treatments. Whereas doctors before had to guess where to inject, the technology enables precise location of the affected nerves and muscles. This increases the efficacy of the drug and reduces unwanted side-effects like muscle weakness.
 
In the next phase, Jog hopes to expand the clinical trial so that personalized therapy can be a widespread option for Parkinson’s and essential tremor patients. 

Additional source: Western University

About the Author
  • I am a human geneticist, passionate about telling stories to make science more engaging and approachable. Find more of my writing at the Hopkins BioMedical Odyssey blog and at TheGeneTwist.com.
You May Also Like
AUG 03, 2020
Cancer
Improving Diagnostics in Breast Cancer
AUG 03, 2020
Improving Diagnostics in Breast Cancer
Diagnostics is one of the essential tools in a physician’s toolkit. A good diagnostic test can identify whether a ...
AUG 17, 2020
Microbiology
Ingestible Bacteria-Catcher Could Act as a Diagnostic Tool
AUG 17, 2020
Ingestible Bacteria-Catcher Could Act as a Diagnostic Tool
Microbes in our gastrointestinal tract may not only be closely linked to our health, but they may also be useful as a di ...
AUG 20, 2020
Clinical & Molecular DX
Machines Learn the Difference Between Autism and Schizophrenia
AUG 20, 2020
Machines Learn the Difference Between Autism and Schizophrenia
 
AUG 25, 2020
Cardiology
Doing More with Less: Making the Diagnosis of Heart Damage Easier for Patients
AUG 25, 2020
Doing More with Less: Making the Diagnosis of Heart Damage Easier for Patients
Cardiovascular health can be a tricky thing to diagnose. Sometimes it can be done with simple heart rate and blood press ...
SEP 09, 2020
Clinical & Molecular DX
Swallow the Pill, Discover the Bugs Within
SEP 09, 2020
Swallow the Pill, Discover the Bugs Within
The 30-foot long human gastrointestinal tract consists of tissues and organs that work in concert to digest our food. Th ...
NOV 03, 2020
Clinical & Molecular DX
"Hello? It's Me, the Coronavirus."
NOV 03, 2020
"Hello? It's Me, the Coronavirus."
Researchers at MIT have discovered an unlikely way of discerning those with COVID-19 from healthy individuals — si ...
Loading Comments...