MAR 24, 2019 1:37 AM PDT

Drug Combination for Pediatric Low-grade Glioma

WRITTEN BY: Nouran Amin

Scientists at the Johns Hopkins Kimmel Cancer Center and the Johns Hopkins University School of Medicine have developed a new drug combination treatment targeted at resistant and recurrent low-grade gliomas particularly in pediatric populations.

The drug combination was shown to slow tumor growth and eradicate tumor cells in laboratory and mouse models. The treatment consists of carboplatin--a standard chemotherapeutic drug that works well against brain tumors, and everolimus—an inhibitory drug that targets an enzyme called mTOR known to fuel tumor growth."We saw dramatic growth inhibition after only a low concentration of everolimus was combined with the carboplatin," says Eric Raabe, M.D., Ph.D., associate professor of oncology and pediatric brain tumor expert at the Johns Hopkins Kimmel Cancer Center.

"We found that everolimus disrupted a key mechanism the cancer cells use to detoxify carboplatin. The ability of everolimus to increase the power of carboplatin suggests this combination could be used effectively in patients."

 

The introduction of everolimus with carboplatin treatment induces DNA damage in tumor cells and kills them. Credit: Johns Hopkins Kimmel Cancer Center

 

Findings of the drug combination study were published Neuro-Oncology and show increased DNA damage in tumor cells followed by cell death in laboratory models. The drug combination showed similar results in mouse models with no added toxicity.

In pediatric low-grade glioma, the most common form of brain tumors in children, surgical interventions for treatment are risky and can affect near optic nerves. However, the drug combination could serve as an effective treatment option.

"The current nationwide clinical study of everolimus in pediatric low-grade glioma requires that some tumor tissue from each patient be evaluated for expression of mTOR markers that might predict response to everolimus," Raabe says. "In this way, we hope to figure out who is most likely to respond to the drug, so that we can move closer to our goal of giving the right medicine to the right patient at the right time. In the future, we may be able to give everolimus along with carboplatin to patients with high-level mTOR expression. Based on our research, we predict that these tumors will likely be resistant to carboplatin unless we simultaneously block mTOR."

Source: John Hopkins Medicine

About the Author
  • Nouran earned her BS and MS in Biology at IUPUI and currently shares her love of science by teaching. She enjoys writing on various topics as well including science & medicine, global health, and conservation biology. She hopes through her writing she can make science more engaging and communicable to the general public.
You May Also Like
JUL 29, 2020
Health & Medicine
The Carrier Oil Matters When it Comes to CBD Products
JUL 29, 2020
The Carrier Oil Matters When it Comes to CBD Products
The type of oil that is used to extract and carry the medicinally active ingredients (cannabinoids and terpenes) in cann ...
AUG 07, 2020
Chemistry & Physics
Excipients: "Inactive" Drug Components Could Be Functioning Beyond Their Scopes
AUG 07, 2020
Excipients: "Inactive" Drug Components Could Be Functioning Beyond Their Scopes
Excipients are chemical additives to medications. They are incorporated into all kinds of pharmaceuticals to fulfil ...
AUG 22, 2020
Drug Discovery & Development
Could a Drug for Bipolar Disorder Treat COVID-19?
AUG 22, 2020
Could a Drug for Bipolar Disorder Treat COVID-19?
Researchers have found that a drug currently used to treat bipolar disorder and hearing loss may also treat COVID-19 tha ...
AUG 06, 2020
Drug Discovery & Development
How Medieval Medicine Can Conquer Modern Day Infections?
AUG 06, 2020
How Medieval Medicine Can Conquer Modern Day Infections?
One of our current global threats is antibiotic resistance.     As more biofilm-associated infections are ...
SEP 08, 2020
Space & Astronomy
New Drug May Allow Astronauts to Spend Years in Space
SEP 08, 2020
New Drug May Allow Astronauts to Spend Years in Space
Without gravity from Earth, muscles and bones tend to weaken quickly. To combat this, astronauts usually need to spend t ...
SEP 01, 2020
Drug Discovery & Development
First Novel Compounds to Inhibit Cancer-Linked Enzymes
SEP 01, 2020
First Novel Compounds to Inhibit Cancer-Linked Enzymes
Researchers from the University of Michigan Rogel Cancer Center have worked on creating a therapeutic-based compound tha ...
Loading Comments...