Improving the solubility and bioavailability of poorly soluble APIs remains one of the toughest challenges in pharmaceutical formulation. There are several proven methods to address it—but many come with tradeoffs in process complexity, environmental impact, or scalability.
Dry amorphization is gaining attention as a viable alternative. While the concept itself isn’t new, recent advances in twin-screw extrusion (TSE) have made it more accessible, efficient, and easier to scale—especially for teams focused on solvent-free or continuous manufacturing strategies.
This free, on-demand short course introduces the principles and practice of dry amorphization using TSE—rooted in peer-reviewed research and guided by a key contributor to the study.
Dr. Margarethe Richter, an application specialist at Thermo Fisher Scientific and corresponding author of the cited paper, explains how she and her colleagues used a blend of mesoporous silica and crystalline itraconazole to achieve up to 90% amorphization at room temperature—with full conversion at just 70°C.
What’s more compelling than the method is what it could mean for you:
If you’re exploring new ways to formulate difficult APIs, this course offers insight into a scalable and solvent-free path.
If you support cross-functional teams in formulation, scale-up, or tech transfer, it can help you speak the language of dry amorphization—and evaluate its fit with your current infrastructure.
And if you're simply expanding your technical fluency, this is a practical, time-efficient way to turn recent research into applicable knowledge.
The course covers:
Why amorphization matters for bioavailability and drug release
How twin-screw extruders can be configured for dry processing without solvents
How analytical methods like DSC, XRD, and SEM validate amorphous conversion
Advantages and considerations for teams moving toward continuous manufacturing
Whether you’re new to dry amorphization—or looking for practical examples to guide adoption—this course provides a grounded, expert-led introduction to the technique and its implications.
Access the short course now and explore the potential of dry amorphization—on your terms, at your pace.
You're almost there!
Fill out the form below to get permanent access to this free Short Course.
Thermo Fisher Scientific Inc. (NYSE: TMO) is the world leader in serving science, with annual revenue of approximately $40 billion. Our Mission is to enable our customers to make the world healthier, cleaner and safer. Whether our customers are accelerating life sciences research, solving complex analytical challenges, increasing productivity in their laboratories, improving patient health through diagnostics or the development and manufacture of life-changing therapies, we are here to support them. Our global team delivers an unrivaled combination of innovative technologies, purchasing convenience and pharmaceutical services through our industry-leading brands, including Thermo Scientific, Applied Biosystems, Invitrogen, Fisher Scientific, Unity Lab Services, Patheon and PPD.
