MAR 03, 2022 4:37 AM PST

Researchers Create the Largest Family Tree, For All Humanity

WRITTEN BY: Carmen Leitch

Mapping your family tree can be a fun and interesting way to learn more about your personal history. Now researchers have done that on a much bigger scale, to create a family tree for the human race. This genealogical effort aims to place all of our ancestry in a larger context. The work has been made possible by the huge advances in genetic and computational technologies that have emerged in recent decades. The genetic data from thousands of people, including some from prehistory, have been analyzed in this study, generating a map of human relations throughout the world. The findings have been reported in Science.

Image credit: Carmen Leitch

This giant family tree for humanity is meant to model the history that has led to the huge amount of genetic variations that humans carry today, explained one of the study's principal investigators, Dr. Yan Wong, an evolutionary geneticist at the Big Data Institute at Oxford University. "This genealogy allows us to see how every person's genetic sequence relates to every other, along all the points of the genome."

We get certain genomic regions that include certain variations from one parent or the other. The ancestry of those regions, with those specific variants, can be used to trace genetic regions back through time. Eventually, one arrives at the point where the genetic variation first emerged.

The research team created a new method to incorporate data from a few different sources. Data from modern and ancient people was obtained from eight databases, for a total of 3,609 genome sequences representing 215 populations. The ancient genomes were anywhere from 1,000 to over 100,000 years old. Computational tools predicted where ancestors could be found in the tree, showing patterns of genetic variation. About 27 million ancestors were seen in this network.

Location data was then overlaid on the genomic data, and where ancestors lived could be visualized. This recapitulated humanity's migration out of Africa.

"Essentially, we are reconstructing the genomes of our ancestors and using them to form a vast network of relationships. We can then estimate when and where these ancestors lived," noted lead study author Dr. Anthony Wilder Wohns, who is now a postdoctoral research at the Broad Institute of MIT and Harvard. "The power of our approach is that it makes very few assumptions about the underlying data and can also include both modern and ancient DNA samples."

The researchers are hoping to add new genetic data to this genealogical map as it becomes available. Millions more genomes could be added eventually. The method can also be extrapolated, noted Wohns, for studying other organisms like bacteria, and could also help reveal links between genetic regions and disease.

Sources: University of Oxford, Science

About the Author
BS
Experienced research scientist and technical expert with authorships on over 30 peer-reviewed publications, traveler to over 70 countries, published photographer and internationally-exhibited painter, volunteer trained in disaster-response, CPR and DV counseling.
You May Also Like
FEB 16, 2022
Drug Discovery & Development
Genome-wide association study increases understanding of the genetic basis of acne
FEB 16, 2022
Genome-wide association study increases understanding of the genetic basis of acne
Acne vulgaris, more commonly known as acne, is the most prevalent skin disease worldwide. While many associate acne with ...
APR 03, 2022
Genetics & Genomics
The Human Genome Sequence is Finally, Truly Complete
APR 03, 2022
The Human Genome Sequence is Finally, Truly Complete
The Human Genome Project was declared complete in 2002. But it wasn't exactly finished. Mysterious, repetitive sequences ...
APR 19, 2022
Immunology
Small Genetic Differences in TB Lead to Very Different Illnesses
APR 19, 2022
Small Genetic Differences in TB Lead to Very Different Illnesses
Tuberculosis is caused by a bacterium, Mycobacterium tuberculosis, that is thought to have been around for about 150 mil ...
JUN 05, 2022
Genetics & Genomics
Height & Health - Being Tall Affects Disease Risk
JUN 05, 2022
Height & Health - Being Tall Affects Disease Risk
Height has long been linked to an increase in the risk of disease, but what's been tough to determine is whether thi ...
JUN 23, 2022
Clinical & Molecular DX
Accelerate diagnostic development with the right supplier
JUN 23, 2022
Accelerate diagnostic development with the right supplier
Diagnostic assays like the one you’re developing are in demand. But your task isn’t simple. Set yourself up ...
JUN 24, 2022
Plants & Animals
New study deepens understanding of how animals see, and what colors
JUN 24, 2022
New study deepens understanding of how animals see, and what colors
We’ve all what animals see. Do they see the same way humans do in terms of colors, or is the vision of each animal ...
Loading Comments...