MAR 15, 2016 1:45 PM PDT

Small, Non-Coding RNA Controls Obesity-Induced Changes in Adipose Tissue

WRITTEN BY: Kara Marker
Obesity and low-grade inflammation often go hand-in-hand with diabetes and heart disease. When lifestyle changes are not enough to reduce the risk of these diseases, scientists look elsewhere for a solution. In a new study published in Circulation Research, scientists from the Brigham and Women’s Hospital identified a small, non-coding RNA as playing a role in changes in adipose tissue.
 
Adipose tissue

The microRNA, called miR-181b, controls adipose tissue vessels, making it responsible for obesity-related changes in those areas. In their study of mice, miR-181b expression was associated with a decrease in adipose tissue in endothelial cells but not in adipocytes. These results were observed after one week of mice being fed a high-fat diet.
 
miR-181b also directly targets a protein phosphatase called PHLPP2. Levels of this protein were found to be higher in endothelial cells from diabetic patients than from non-diabetic patients. Therefore, inhibiting PHLPP2 and boosting miR-181b expression are on the “to-do” list of the researchers involved in this study.
 
miRNA Biogenesis

 
Scientists believe that they can rebuild the healthy levels of miR-181b of unhealthy people to decrease insulin resistance that causes and exacerbates diabetes. Initial successes are promising: scientists giving miR-181b injections saw improved insulin sensitivity, improved glucose levels, and reduced inflammation. The same results showed with PHLPP2 inhibition.
 
"The beneficial role of this microRNA in obesity is likely the tip of the iceberg since excessive inflammation is a pervasive finding in a wide-range of chronic inflammatory diseases,” said senior author Mark Feinberg, MD.
 
 
Source: Brigham and Women’s Hospital
 
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
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