FEB 25, 2015 11:18 PM PST

Obesity Genes Identified by Worldwide Research Team

A massive worldwide analysis of genetic data from almost 340,000 people around the world has brought understanding of the genetic basis of obesity a step closer.

Associate Professor Dale Nyholt, from QUT's Institute of Health and Biomedical Innovation and QIMR, is one of 483 scientists in 363 research centres across the world who contributed data for a meta-analysis of genetic differences in people's BMI (body mass index), the commonly used measure of obesity and fatty tissue stored by the body.

The findings, published in Nature, give new insights into possible weight-loss therapies and the prevention of metabolic-associated diseases.

"Obesity is heritable and predisposes people to many other diseases," Professor Nyholt said.

"It is a worldwide epidemic which imposes an enormous burden on individual and public health."

"To better understand the genetic basis of obesity, we conducted the world's largest genome-wide association study and Metabochip meta-analysis of body mass index (BMI) in up to 339,224 people."

Professor Nyholt said that while it was known that 40 to 70percent of the difference in BMI in the population could be attributed to genetic factors, most of the genetic variability was still unexplained.

"While analyses of previous genetic association results have suggested some intriguing biological processes underlying a person's susceptibility to obesity, few specific genes were involved in a defined biological pathway, which represents a series of actions among molecules in a cell that leads to a certain product or a change in a cell.

"This means that for most of the implicated genomic regions (loci) the likely causal gene or genes and their pathways remained unknown until now."

Professor Nyholt said the global team of scientists identified 97 genetic markers strongly associated with influencing BMI, and 56 of these were completely new, after meta-analysing more than 2.5 million single variations of nucleotides, the molecules that make up DNA.

"These analyses pointed to particular genes and biological pathways that affect BMI.

These genes include neurotransmitters that respond to changes in eating and fasting whose pathways could reveal more targets for weight-loss therapies."

Professor Nyholt said BMI-associated genetic markers also overlapped with genes and pathways affecting the brain's development and had a role in the central nervous system in regulating BMI.

"Together, these findings highlight the diverse causes of obesity and its link with many other related metabolic diseases.

"When we better understand these mechanisms, it may help explain why not all obese individuals develop metabolic disease and suggest possible mechanisms to prevent people who are obese developing metabolic disease."

Source: Queensland University of Technology
About the Author
  • Ilene Schneider is the owner of Schneider the Writer, a firm that provides communications for health care, high technology and service enterprises. Her specialties include public relations, media relations, advertising, journalistic writing, editing, grant writing and corporate creativity consulting services. Prior to starting her own business in 1985, Ilene was editor of the Cleveland edition of TV Guide, associate editor of School Product News (Penton Publishing) and senior public relations representative at Beckman Instruments, Inc. She was profiled in a book, How to Open and Operate a Home-Based Writing Business and listed in Who's Who of American Women, Who's Who in Advertising and Who's Who in Media and Communications. She was the recipient of the Women in Communications, Inc. Clarion Award in advertising. A graduate of the University of Pennsylvania, Ilene and her family have lived in Irvine, California, since 1978.
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