MAR 09, 2015 10:07 PM PDT

Researchers Report New Gene Associated With Thyroid Levels

WRITTEN BY: Ilene Schneider
Thyroid hormones have important and diverse roles in human health and regulate metabolic rate. Thyroid disease is common (affecting 5-10 per cent of the population) and synthetic thyroid hormones are one of the commonest drug therapies prescribed worldwide. A new study, published in Nature Communications involving University of Bristol academics, reports a new gene called SYN2 associated with thyroid levels.

Researchers found the SYN2 gene plays an important role in the control of thyroid stimulating hormone. The study also reports a separate, rare, genetic variant present in only four individuals per 1,000 people that can cause thyroxine levels in the blood to be elevated. Although thyroid hormones are essential for childhood development and maintaining adult health, the genetic control of these important hormones is poorly understood.

Data collected from around 4,000 people in the UK and cohorts in Europe and Australia enabled scientists to discover genes and mechanisms affecting the thyroid.

Dr Peter Taylor from the Institute of Molecular and Experimental Medicine at Cardiff University, said: "Thanks to the detailed genetic data available through a whole genome sequencing study, the UK10K project, we identified rare variants associated with thyroid hormone levels which could not have been detected in earlier studies."

The whole genomes which formed the basis of the study come from two important groups of people who have been studied for many years - the TwinsUK Adult Twin Registry and probably the most well studied adults in the world, and the University of Bristol's ALSPAC (Avon Longitudinal Study of Parents and Children) studies. The data for each group include extensive descriptions of their health and their development. Additional participants were from Busselton, Australia and Sardinia and Val Borbera, Italy.

Professor Scott Wilson, the study's lead author, said: "This whole genome sequence data has enabled us to identify that both common genetic variants with modest effects and rarer genetic variants with larger effects determine an individual's thyroid status."

Professor Tim Spector, who leads the TwinsUK study at King's College London said, "We are fortunate to have such excellent collections of clinical research material provided by altruistic volunteers to help in medical research." More than 16,000 volunteers have contributed to this research across several countries. The base data comes from the largest genome-sequencing project so far completed. "It's humbling to see the generosity of participants in these studies. The success comes from combining the largest genome sequencing projects performed to date with the most well characterised population samples in the world."

This is one of the first in a series of UK10K studies using whole genome sequence data and clinical information to identify genetic variants which influence health right across the frequency spectrum

Dr Nicholas Timpson, one of the co-authors from the Medical Research Council (MRC) Integrative Epidemiology Unit at the University of Bristol said: "This work is another example of how extending gene studies to include whole genome sequencing can identify new clinically informative variants and enhance our understanding of key biological processes. The UK10K project has been essential to this endeavor and we are now beginning to realize its potential."

Source: University of Bristol
About the Author
  • Ilene Schneider is the owner of Schneider the Writer, a firm that provides communications for health care, high technology and service enterprises. Her specialties include public relations, media relations, advertising, journalistic writing, editing, grant writing and corporate creativity consulting services. Prior to starting her own business in 1985, Ilene was editor of the Cleveland edition of TV Guide, associate editor of School Product News (Penton Publishing) and senior public relations representative at Beckman Instruments, Inc. She was profiled in a book, How to Open and Operate a Home-Based Writing Business and listed in Who's Who of American Women, Who's Who in Advertising and Who's Who in Media and Communications. She was the recipient of the Women in Communications, Inc. Clarion Award in advertising. A graduate of the University of Pennsylvania, Ilene and her family have lived in Irvine, California, since 1978.
You May Also Like
OCT 28, 2021
Cell & Molecular Biology
The Production & Export of Ribosomal Subunits is Caught on Video
OCT 28, 2021
The Production & Export of Ribosomal Subunits is Caught on Video
Protein production is essential for life; cells use DNA to transcribe active genes into RNA sequences, and ribosomes tra ...
NOV 07, 2021
Cell & Molecular Biology
How Cells Use Messengers to Signal to One Another
NOV 07, 2021
How Cells Use Messengers to Signal to One Another
In recent years, researchers have discovered the importance of a kind of antenna that is found on most cells, a structur ...
NOV 07, 2021
Genetics & Genomics
New Model Teaches Us More About Why the Delta Variant is So Infectious
NOV 07, 2021
New Model Teaches Us More About Why the Delta Variant is So Infectious
When the COVID-19 pandemic began to impact the world, researchers everywhere sprang into action. But studying an infecti ...
NOV 16, 2021
Clinical & Molecular DX
Algorithm Mines Big Data, Finds Gene Linked to Psychiatric Disease
NOV 16, 2021
Algorithm Mines Big Data, Finds Gene Linked to Psychiatric Disease
We have a wealth of human genome data overlaid with gene ‘hotspots’ linked to the development of particular ...
DEC 10, 2021
Genetics & Genomics
In Microgravity, There are More Errors During DNA Replication
DEC 10, 2021
In Microgravity, There are More Errors During DNA Replication
The radiation in space is not great for biological health. Space radiation is known to damage DNA. Many types of human c ...
DEC 15, 2021
Microbiology
A Genetic Modification Alters Bacterial Behavior to Produce Artistic Swirls
DEC 15, 2021
A Genetic Modification Alters Bacterial Behavior to Produce Artistic Swirls
Researchers engineered a genetic circuit to make pathogenic bacteria called Myxococcus xanthus move in swirled patterns.
Loading Comments...