APR 03, 2015 8:26 AM PDT

New research: DNA can't explain all inherited biological traits

WRITTEN BY: Robert Woodard
New research shows that characteristics passed between generations are not decided solely by DNA, but can be brought about by other material in cells.

Scientists studied proteins found in cells, known as histones, which are not part of the genetic code, but act as spools around which DNA is wound. Histones are known to control whether or not genes are switched on.

Researchers found that naturally occurring changes to these proteins, which affect how they control genes, can be sustained from one generation to the next and so influence which traits are passed on.

The finding demonstrates for the first time that DNA is not solely responsible for how characteristics are inherited. It paves the way for research into how and when this method of inheritance occurs in nature, and if it is linked to particular traits or health conditions.

It may also inform research into whether changes to the histone proteins that are caused by environmental conditions - such as stress or diet - can influence the function of genes passed on to offspring.

The research confirms a long-held expectation among scientists that genes could be controlled across generations by such changes. However, it remains to be seen how common the process is, researchers say.

Scientists tested the theory by carrying out experiments in a yeast with similar gene control mechanisms to human cells. They introduced changes to a histone protein, mimicking those that occur naturally, causing it to switch off nearby genes. The effect was inherited by subsequent generations of yeast cells.

The study, published in Science, was supported by the Wellcome Trust and the EC EpiGeneSys Network.
Professor Robin Allshire, of the University of Edinburgh's School of Biological Sciences, who led the study, said: "We've shown without doubt that changes in the histone spools that make up chromosomes can be copied and passed through generations. Our finding settles the idea that inherited traits can be epigenetic, meaning that they are not solely down to changes in a gene's DNA."

Source: phys.org
About the Author
You May Also Like
MAR 25, 2020
Technology
MAR 25, 2020
What is eDNA?
What exactly is eDNA? It is environmental DNA that has underwent the next-generation sequencing and that has been &lsquo ...
MAR 29, 2020
Genetics & Genomics
MAR 29, 2020
Biomarkers That Predict Crohn's Disease Are Identified
A series of studies published in Gastroenterology has outlined new approaches in predicting IBD.
MAY 25, 2020
Genetics & Genomics
MAY 25, 2020
FDA Approves the First Treatment for Neurofibromatosis 1
In a major breakthrough, the Food and Drug Administration has approved a treatment for a genetic disorder called neurofi ...
JUN 01, 2020
Microbiology
JUN 01, 2020
The Most Common Marine Microbe Has a Virus in Its Genome
Single-celled ocean microbes known as Pelagibacter or SAR11 make up about 25 percent of the plankton on the planet.
JUN 24, 2020
Microbiology
JUN 24, 2020
Genetic Variations Can Affect the Gut Microbiome
The small variations in the human genome aren't the only thing that make us unique. We also each carry communities of mi ...
JUL 05, 2020
Microbiology
JUL 05, 2020
Stimulating Antibiotic Production in Bacteria
The microorganisms of the world have to compete for survival, and they sometimes do battle with one another. Some use an ...
Loading Comments...