NOV 02, 2022 9:00 AM PDT

[White Paper] Optimizing Sequencing Costs in Metagenomics. How to Reduce Costs of Pathogen Detection with PaRTI-Seq™

SPONSORED BY: Micronbrane Medical

Optimizing sequencing costs in metagenomics: How to reduce costs of pathogen detection in with PaRTI-Seq™

Pathogen detection techniques based on culture PCR, or serology are still regarded as the gold standards for pathogen detection, even though these techniques present significant limitations due to their turnover time, low positivity rates and low sensitivity. Next-generation sequencing (NGS) techniques are capable of addressing many of these shortcomings with the high-throughput approach of nucleic acid sequencing, in which millions to billions of short fragments of DNA (reads) or RNA (transcripts) are massively sequenced in parallel (Behjati and Tarpey, 2013). With the help of bioinformatics, these fragments can then be assembled and mapped against a reference database for fast and accurate pathogen identification. NGS-based approaches have the potential to significantly improve throughput capabilities of clinical laboratories, while also enhancing detection sensitivity and resolution.

Despite the increasing affordability of sequencing per megabase of DNA, sequencing costs still represent a major portion (up to 80%) of the total costs associated with the employment of NGS-based techniques in clinical settings.

While the cost of sequencing and turn-around times (TAT) associated with NGS have been consistently decreasing (Wetterstrand, 2021), host DNA interference still presents a major limitation that withholds NGS from mass adoption in clinical settings today.  A major driver for the reduction of cost and TAT of the sequencing run is an effective host depletion method. The products offered by Micronbrane, Devin™ filter and PaRTI-Seq™, offer healthcare providers a new complete solution that makes NGS pathogen detection for clinical diagnostics of infectious diseases faster, and at the same time, more efficient and affordable.

This white paper gives a detailed explanation on how Micronbrane’s products (PaRTI-Seq™) can save up to 75% of sequencing costs and reduce more than a half of overall costs for such tests in clinical settings while providing accurate results within 24 hours.

Read full version now

Download White Paper in pdf

Watch more about Micronbrane and how PaRTI-Seq™ works in video:

About the Sponsor
We are Biotechnology Startup company based in Taiwan Our goal is to enable the pathogen detection from whole blood within 24 hours available and affordable. Anywhere. Any time. We develop and deliver reagents, consumables and analytical software for clinical pathogenic microorganism detection worldwide.
You May Also Like
Loading Comments...