MAR 15, 2016 12:05 PM PDT

Protecting Babies From Serious Lung Infections

WRITTEN BY: Kara Marker
For healthy adults and older children, respiratory syncytial virus (RSV) is not a serious issue, but the infection can be life-threatening for infants and young children. New human and mouse studies have identified a naturally-produced compound that fights RSV, and now scientists are looking for ways to naturally boost its production.
RSV is common and usually just produces cold-like symptoms. However for infants and young children at a heightened risk for RSV, those regularly attending daycare, experiencing second-hand smoke, have school-aged siblings, or endure crowded living situations, RSV infection can become quite severe (Medline Plus). There are several symptoms that accompany a serious RSV infection:
  • Cyanosis
  • Difficulty breathing
  • Nasal flaring
  • Wheezing
When severe RSV infections cause hospital visits, treatment can consist of oxygen, humidified air, IV fluids, and ventilation.
RSV Structure

In their study of mice and healthy adults published in the Journal of Immunology, University of Edinburgh scientists at the MRC Centre for Inflammation Research pinpointed a naturally-produced compound called cathelicidin as having a large role in the immune attack against RSV. During their study, mice unable to produce cathelicidin like normal were more susceptible to RSV infection. However, when simultaneously treated with cathelicidin during their RSV infection, their bodies were able to fight off the infection like normal mice.
Humans, too, had a clear connection to cathelicidin. Healthy adults who produced lower levels of cathelicidin, for unknown reasons so far, were more susceptible to RSV, like the mice who could not produce the compound at all. Based on these findings, scientists are hoping to find ways to “encourage” the immune system to produce more cathelicidin, especially for high-risk groups of infants and young children.
Cathelicidin works by directly attacking RSV particles, preventing them from attaching to and penetrating host cells. Cathelicidin could also be a new therapy for RSV, and scientists are especially looking for natural ways to boost compound production.
Enhancing the treatment arsenal for RSV is certainly beneficial for infants and young children, but it is also valuable for elderly people who, like infants, constitute a population especially vulnerable to life-threatening versions of the disease.
“Boosting the body's natural defenses could be a useful therapeutic approach to stop RSV infection from turning into a life-threatening infection in babies and vulnerable adults,” said Dr. Donald Davidson.
Davidson and other Edinburgh scientists are asking this question next: why do people differ in the amount of cathelicidin they produce?
Source: University of Edinburgh
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog:
You May Also Like
MAY 14, 2020
Chemistry & Physics
MAY 14, 2020
Do Organic Chemists Speak an Alien Language?
Have you ever read a detergent label and got confused? Or had trouble understanding a medication recall? Certain ch ...
MAY 15, 2020
MAY 15, 2020
Support the Microbiome So the Immune System Can Do Its Job
Research has long connected the human microbiome and immune system function, and now a recent study pinpoints a key poin ...
MAY 26, 2020
Clinical & Molecular DX
MAY 26, 2020
Nanoengineering Aids Bladder Cancer Detection
MAY 24, 2020
MAY 24, 2020
Cavity-Causing Microbes Are Protected by Rings of Sugars and Germs
Bacteria can form tough communities called biofilms, which are difficult to remove and can resist the effects of antimic ...
MAY 26, 2020
Genetics & Genomics
MAY 26, 2020
Some People May be Predisposed to Metastasis if They Get Cancer
Cancer can occur for many reasons and is influenced by many different factors, including genes and the environment. But ...
MAY 31, 2020
MAY 31, 2020
Zika Virus Infections in Early Life Can Cause Brain Damage
The Zika virus, which is transmitted by Aedes mosquitoes, poses significant risks to the developing fetus, and new work ...
Loading Comments...