MAY 31, 2016 6:44 PM PDT

Is Malnutrition An Immune Disorder?

WRITTEN BY: Kara Marker
Malnourishment encompasses both under- and overnutrition, and for the approximately five million children that die each year from these conditions, most die from common, preventable infections, as opposed to starvation. In a review published in Trends in Immunology, scientists discuss the infinite relationship between malnourishment and immune defects. 
 

"That traditional image of malnutrition that we're unfortunately so familiar with, of someone wasting away, that's just the external picture," said first author Claire Bourke, PhD. Bourke is talking about the hidden reality behind malnourished children. It is not always an unhealthy diet that causes this condition. A predisposition for malnourishment as predestined by a child’s genetic makeup plays a primary role in determining a child’s outcome. With the right mix of genes passed down from parents, a child could experience malnourishment even while consuming a healthy diet.

How is this possible? Scientists are quickly realizing, with new tools to study immunodeficiency, that immune defects cause malnutrition just as much as malnutrition causes immune defects. Immune dysfunction appears causative in the form of malabsorption, increased metabolic demand, dysregulation of the growth hormone, and greater susceptibility to infection - factors which exacerbate a malnourished condition.

“It doesn't just fight infection,” Bourke said of the human immune system. “It affects metabolism, neurological function, and growth, which are things that are also impaired in malnutrition."

On the other end of the spectrum, malnutrition can cause pro-inflammatory conditions from impairing function of dendritic cells, monocytes, and effector memory T cells. Together, immune dysfunction and malnourishment can create a state of impaired gut function and increased susceptibility to infection.

Scientists are now realizing the intricacies of the relationship between the immune system and nutrition by recognizing the connection between low numbers of white blood cells, weak skin and gut membranes, and malfunctioning lymph nodes.

Another part of the story is the epigenetic changes that occur in malnourished people that can persist through several generations. Children of malnourished parents have the potential of being affected very similarly by malnourishment, even if they make healthful eating choices. This effect is due to the inheritance of immune and metabolic genes, the expression of which has changed from a lifestyle of malnourishment. 

Over half of all deaths in children five years old and younger are due to undernutrition. Even more, researchers find that the first thousand days of a baby’s life are extremely sensitive to diet and other environmental factors. With a new understanding how the malnutrition can be seen as an immune disorder, scientists are hopeful that reducing the prevalence of malnourished generations can help to reduce the burden of child mortality.
 
 

Sources: Cell Press, UNICEF, World Health Organization
About the Author
  • I am a scientific journalist and enthusiast, especially in the realm of biomedicine. I am passionate about conveying the truth in scientific phenomena and subsequently improving health and public awareness. Sometimes scientific research needs a translator to effectively communicate the scientific jargon present in significant findings. I plan to be that translating communicator, and I hope to decrease the spread of misrepresented scientific phenomena! Check out my science blog: ScienceKara.com.
You May Also Like
JAN 13, 2020
Cardiology
JAN 13, 2020
Drinking Tea Linked to Better Heart Health
Researchers from the Chinese Academy of Medical Sciences in Beijing have found that drinking black or green tea three or more times per week helps improve ...
JAN 28, 2020
Clinical & Molecular DX
JAN 28, 2020
Protein complex discovered as first biomarker of PTSD
  Researchers at the Centre for Addiction and Mental Health (CAMH) and the Canadian Institutes of Health Research (CIHR) have identified a potential d...
JAN 28, 2020
Genetics & Genomics
JAN 28, 2020
Developing a Gene Therapy to Treat Duchenne Muscular Dystrophy
Because of a genetic mutation, people that have Duchenne muscular dystrophy lack functional copies of a protein called dystrophin....
FEB 05, 2020
Cardiology
FEB 05, 2020
Protein-Rich Foods May Damage Heart Health
High-protein diets are becoming more and more popular as a method to both increase muscle mass and lose weight. Now however, new research is showing that e...
FEB 15, 2020
Clinical & Molecular DX
FEB 15, 2020
FDA nod for AI-powered technology to detect strokes
The US Food and Drug Administration (FDA) has provided clearance for a novel technology that uses artificial intelligence (AI) to detect strokes. The platf...
FEB 16, 2020
Microbiology
FEB 16, 2020
Images of Coronavirus Are Released as First Death Outside China is Reported
Previously known as 2019-nCoV, the virus has a new name: SARS-CoV-2, which is the cause of what's being called COVID-19 disease....
Loading Comments...